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Titolo:
Dale's principle and glutamate corelease from ventral midbrain dopamine neurons
Autore:
Sulzer, D; Rayport, S;
Indirizzi:
Columbia Univ, Dept Psychiat, New York, NY USA Columbia Univ New York NY USA mbia Univ, Dept Psychiat, New York, NY USA Columbia Univ, Dept Neurol, New York, NY USA Columbia Univ New York NY USA lumbia Univ, Dept Neurol, New York, NY USA Columbia Univ, NYS Psychiat Inst, Dept Neurosci, New York, NY USA ColumbiaUniv New York NY USA hiat Inst, Dept Neurosci, New York, NY USA Columbia Univ, Dept Anat & Cell Biol, New York, NY USA Columbia Univ New York NY USA v, Dept Anat & Cell Biol, New York, NY USA Columbia Univ, Ctr Neurobiol & Behav, New York, NY 10032 USA Columbia Univ New York NY USA 10032 obiol & Behav, New York, NY 10032 USA
Titolo Testata:
AMINO ACIDS
fascicolo: 1, volume: 19, anno: 2000,
pagine: 45 - 52
SICI:
0939-4451(2000)19:1<45:DPAGCF>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
VESICULAR GABA TRANSPORTER; SYNAPTIC TRANSMISSION; NUCLEUS-ACCUMBENS; SPINAL-CORD; RELEASE; MICROCULTURES; RECEPTORS; SYNAPSES; GLYCINE; BRAIN;
Keywords:
amino acids; autapses; VMAT2; substantia nigra; ventral tegmental area; phosphate-activated glutaminase; tyrosine hydroxylase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Sulzer, D Black Bldg,Room 305,650 W 168th St, New York, NY 10032 USA Black Bldg,Room 305,650 W 168th St New York NY USA 10032 32 USA
Citazione:
D. Sulzer e S. Rayport, "Dale's principle and glutamate corelease from ventral midbrain dopamine neurons", AMINO ACIDS, 19(1), 2000, pp. 45-52

Abstract

While direct application of dopamine modulates postsynaptic activity, electrical stimulation of dopamine neurons typically evokes excitation. Most ofthis excitation appears to be due to activation of collateral pathways; however, several lines of evidence have suggested that there is a monosynaptic component due to glutamate corelease by dopamine neurons. Recently, more direct evidence obtained in culture has shown that ventral midbrain dopamine neurons release both dopamine and glutamate. Moreover, they appear to do so from separate release sites, calling into question recent modifications of Dale's Principle. The neurochemical phenotype of a given synapse may be determined by subcellular neurotransmitter levels, uptake, or storage. However, the relationship between dopamine and glutamate release from dopamine neuron synapses in the intact brain - and the mechanisms involved - has yetto be resolved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 15:27:28