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Titolo:
Increased leukocyte aggregation induced by gamma-globulin: A clue to the presence of pseudoleukopenia
Autore:
Zeltser, D; Fusman, R; Chapman, J; Rotstein, R; Shapira, I; Elkayam, O; Eldor, A; Arber, N; Berliner, S;
Indirizzi:
Tel Aviv Univ, Sackler Fac Med, Tel Aviv Sourasky Med Ctr, Dept Internal Med D, IL-64239 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-64239 Med D, IL-64239 Tel Aviv, Israel Tel Aviv Univ, Sackler Fac Med, Tel Aviv Sourasky Med Ctr, Dept Neurol, IL-64239 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-64239 Neurol, IL-64239 Tel Aviv, Israel Tel Aviv Univ, Sackler Fac Med, Tel Aviv Sourasky Med Ctr, Dept Rheumatol,IL-64239 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-64239 eumatol,IL-64239 Tel Aviv, Israel Tel Aviv Univ, Sackler Fac Med, Tel Aviv Sourasky Med Ctr, Dept Hematol, IL-64239 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-64239 ematol, IL-64239 Tel Aviv, Israel Tel Aviv Univ, Sackler Fac Med, Tel Aviv Sourasky Med Ctr, Dept Gastroenterol, IL-64239 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-64239 nterol, IL-64239 Tel Aviv, Israel
Titolo Testata:
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
fascicolo: 3, volume: 320, anno: 2000,
pagine: 177 - 182
SICI:
0002-9629(200009)320:3<177:ILAIBG>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRAVENOUS IMMUNOGLOBULIN THERAPY; INVITRO GRANULOCYTE AGGREGATION; IMMUNE GLOBULIN; DISEASE-ACTIVITY; BLOOD; NEUTROPENIA; INFARCTION; LEUKERGY; AGGLUTINATION; LEUKOPENIA;
Keywords:
gamma-globulin; leukocyte aggregation; pseudoleukopenia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Berliner, S Tel Aviv Univ, Sackler Fac Med, Tel Aviv Sourasky Med Ctr, Dept Internal Med D, 6 Weizman St, IL-64239 Tel Aviv, Israel Tel Aviv Univ 6 Weizman St Tel Aviv Israel IL-64239 v, Israel
Citazione:
D. Zeltser et al., "Increased leukocyte aggregation induced by gamma-globulin: A clue to the presence of pseudoleukopenia", AM J MED SC, 320(3), 2000, pp. 177-182

Abstract

Background: Previous articles have reported the appearance of leukopenia after the administration of high-dose intravenous gamma-globulins. Methods: A simple slide test was used to reveal the state of leukocyte aggregation (LA) in the peripheral blood as well as the absolute number of leukocytes inthe slides. Results: A significant (P < 0.00001) increment was noted in the state of LA, from 9 +/- 6% before to 25 +/- 11% after gamma-globulin administration. This was accompanied by a significant (P < 0.0004) reduction inthe number of white blood cells in the peripheral blood (from 8433 +/- 3905 to 6550 +/- 3252 cells/mm(3)) but no significant change in the absolute number of the cells as determined by the leukocyte count per high power field in the peripheral slides. Conclusions: We raise the possibility that the leukopenia reported in some patients after the intravenous administration of high dose gamma-globulin is explained in part by the agglutination effectof the drug.

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Documento generato il 03/07/20 alle ore 16:23:23