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Titolo:
Differential cardiorespiratory effects of endomorphin 1, endomorphin 2, DAMGO, and morphine
Autore:
Czapla, MA; Gozal, D; Alea, OA; Beckerman, RC; Zadina, JE;
Indirizzi:
Vet Adm Med Ctr, Neurosci Lab, New Orleans, LA 70112 USA Vet Adm Med Ctr New Orleans LA USA 70112 i Lab, New Orleans, LA 70112 USA Tulane Univ, Sch Med, Constance S Kaufman Pediat Pulm Res Lab, New Orleans, LA 70112 USA Tulane Univ New Orleans LA USA 70112 m Res Lab, New Orleans, LA 70112 USA Tulane Univ, Sch Med, Dept Pediat, New Orleans, LA 70112 USA Tulane Univ New Orleans LA USA 70112 pt Pediat, New Orleans, LA 70112 USA Tulane Univ, Sch Med, Dept Physiol, New Orleans, LA 70112 USA Tulane UnivNew Orleans LA USA 70112 t Physiol, New Orleans, LA 70112 USA Tulane Univ, Sch Med, Dept Neurosci, New Orleans, LA 70112 USA Tulane Univ New Orleans LA USA 70112 Neurosci, New Orleans, LA 70112 USA Tulane Univ, Sch Med, Dept Med, New Orleans, LA 70112 USA Tulane Univ NewOrleans LA USA 70112 Dept Med, New Orleans, LA 70112 USA
Titolo Testata:
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
fascicolo: 3, volume: 162, anno: 2000,
pagine: 994 - 999
SICI:
1073-449X(200009)162:3<994:DCEOE1>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
MU-OPIOID RECEPTOR; INDUCED RESPIRATORY DEPRESSION; SUPRASPINAL ANTINOCICEPTION; ENDOGENOUS LIGANDS; BRAIN-STEM; IN-VITRO; RAT; ACTIVATION; ANALGESIA; MICE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Zadina, JE Vet Adm Med Ctr, Neurosci Lab, 151,1601 Perdido St, New Orleans, LA 70112 USA Vet Adm Med Ctr 151,1601 Perdido St New Orleans LA USA 70112SA
Citazione:
M.A. Czapla et al., "Differential cardiorespiratory effects of endomorphin 1, endomorphin 2, DAMGO, and morphine", AM J R CRIT, 162(3), 2000, pp. 994-999

Abstract

The novel endogenous mu-opioid receptor (MOR) agonists endomorphin 1 (EM1)and 2 (EM2) were tested for their cardiorespiratory effects in conscious, freely behaving rats. After systemic (intravenous) administration of EM1, EM2, or the selective MOR agonist DAMGO, analgesia, minute ventilation ((V) over dot E), heart rate (HR) and mean arterial blood pressure (BP) were measured. The threshold dose for analgesia was similar for all 3 peptides (similar to 900 nmol/kg). All 3 compounds elicited biphasic (V) over dot E responses, with marked, short-lived (V) over dot E depressions (4-6 s) followedby more sustained (V) over dot E increases (10-12 min). However, compared with responses elicited by EM2 or DAMGO, EM1 decreased (V) over dot E only at higher doses, and produced greater (V) over dot E stimulation. Morphine produced a (V) over dot E decrease, but no subsequent (V) over dot E increase. EM2 and DAMGO decreased HR and BP, while EM1 decreased HR, but did not decrease BP in conscious rats at doses up to 9,600 nmol/kg. In anesthetizedrats, all 3 peptides decreased HR and BP. The decreases in (V) over dot E,HR, and BP were blocked by the MOR antagonist, naloxone HCl (NIx). Only the HR and BP responses, however, were blocked by naloxone-methiodide (MeNIx), indicating central mediation of VE responses and peripheral mediation of cardiovascular responses. We conclude that MOR-selective compounds vary in their cardiorespiratory response characteristics which could be linked to differential cellular actions. The results support the concept that the analgesic, respiratory, and cardiovascular effects of MOR agonists can be dissociated and that EM1-like compounds could provide the basis for novel, saferanalgesics.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 11:26:56