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Titolo:
Timing of administration of anti-VLA-4 differentiates airway hyperresponsiveness in the central and peripheral airways in mice
Autore:
Kanehiro, A; Takeda, K; Joetham, A; Tomkinson, A; Ikemura, T; Irvin, CG; Gelfand, EW;
Indirizzi:
Natl Jewish Med & Res Ctr, Dept Pediat, Div Basic Sci, Denver, CO 80206 USA Natl Jewish Med & Res Ctr Denver CO USA 80206 c Sci, Denver, CO 80206 USA Natl Jewish Med & Res Ctr, Dept Med, Denver, CO 80206 USA Natl Jewish Med & Res Ctr Denver CO USA 80206 t Med, Denver, CO 80206 USA
Titolo Testata:
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
fascicolo: 3, volume: 162, anno: 2000,
pagine: 1132 - 1139
SICI:
1073-449X(200009)162:3<1132:TOAOAD>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-ADHESION MOLECULE-1; LATE ACTIVATION ANTIGEN-4; BRONCHIAL HYPERRESPONSIVENESS; ENDOTHELIAL-CELLS; ALPHA-4 INTEGRINS; HUMAN EOSINOPHIL; LYMPHOCYTES-T; ATOPIC ASTHMA; GUINEA-PIG; IN-VIVO;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Gelfand, EW Natl Jewish Med & Res Ctr, Dept Pediat, Div Basic Sci, 1400 Jackson St, Denver, CO 80206 USA Natl Jewish Med & Res Ctr 1400 Jackson St Denver CO USA 80206
Citazione:
A. Kanehiro et al., "Timing of administration of anti-VLA-4 differentiates airway hyperresponsiveness in the central and peripheral airways in mice", AM J R CRIT, 162(3), 2000, pp. 1132-1139

Abstract

The development of airway hyperresponsiveness (AHR) is correlated with theinfiltration into the lungs of activated eosinophils and T lymphocytes. Inlarge part, influx of eosinophils into the lung is dependent on very late activating antigen-4 (VLA-4) expression. However, the kinetics of eosinophil recruitment and the development of AHR are not fully delineated. Airway function was monitored by changes in lung resistance (RL) and dynamic compliance (Cdyn) to methacholine (MCh) inhalation after anti-VLA-4. After ovalbumin (OVA) sensitization and airway challenge of BALB/c mice, AHR increased as did the number of lung inflammatory cells. Administration of anti-VLA-4 to sensitized mice 2 h before the first (of three) OVA airway challenges significantly prevented changes in RL. Moreover, injection of the antibody from 2 h before the first challenge to 42 h after the last challenge significantly prevented the increases in RL, as well as eosinophil and lymphocyte numbers in the bronchoalveolar lavage fluid (BALF); interleukin-5 (IL-5) andleukotriene concentrations in BALF were also significantly inhibited. Interestingly, treatment with anti-VLA-4 only prevented changes in Cdyn and goblet cell hyperplasia when administered 2 h before the first challenge. These studies demonstrate that the timing of anti-VLA-4 administration can selectively affect pathologic processes that contribute to altered airway function in the central and peripheral airways after allergen challenge.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 17:44:37