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Titolo:
Insulin resistance and endothelial dysfunction in smokers: effects of vitamin C
Autore:
Hirai, N; Kawano, H; Hirashima, O; Motoyama, T; Moriyama, Y; Sakamoto, T; Kugiyama, K; Ogawa, H; Nakao, K; Yasue, H;
Indirizzi:
Kumamoto Univ, Sch Med, Dept Cardiovasc Med, Kumamoto 8608556, Japan Kumamoto Univ Kumamoto Japan 8608556 iovasc Med, Kumamoto 8608556, Japan Kyoto Univ, Grad Sch Med, Dept Med & Clin Sci, Kyoto 6068507, Japan Kyoto Univ Kyoto Japan 6068507 Dept Med & Clin Sci, Kyoto 6068507, Japan
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
fascicolo: 3, volume: 279, anno: 2000,
pagine: H1172 - H1178
SICI:
0363-6135(200009)279:3<H1172:IRAEDI>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHESIS; CIGARETTE-SMOKE; ASCORBIC-ACID; CARDIOVASCULAR-DISEASE; SOMATOSTATIN ANALOG; CORONARY-ARTERIES; GLUCOSE-UPTAKE; FREE-RADICALS; IN-VIVO; ATHEROSCLEROSIS;
Keywords:
oxidative stress; cigarette smoking; insulin sensitivity; endothelial function;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Yasue, H Kumamoto Univ, Sch Med, Dept Cardiovasc Med, 1-1-1 Honjo, Kumamoto 8608556, Japan Kumamoto Univ 1-1-1 Honjo Kumamoto Japan 8608556 8608556, Japan
Citazione:
N. Hirai et al., "Insulin resistance and endothelial dysfunction in smokers: effects of vitamin C", AM J P-HEAR, 279(3), 2000, pp. H1172-H1178

Abstract

Cigarette smoking impairs endothelial function and is one of the major risk factors for atherosclerosis and coronary heart disease. Insulin resistance is associated with major risk factors for atherosclerosis. We examined the effects of vitamin C on insulin sensitivity and endothelial function by measuring steady-state plasma glucose (SSPG) and flow-mediated dilation (FMD) of the brachial artery. We studied 16 current smokers with normal glucosetolerance, 15 nonsmokers with impaired glucose tolerance (IGT), and 17 nonsmokers with normal glucose tolerance as controls. Both SSPG and FMD were blunted in smokers and nonsmokers with IGT compared with controls. In smokers, vitamin C decreased SSPG (P < 0.01 by ANOVA) with decreasing plasma thiobarbituric acid-reactive substances (TBARS) (P < 0.05 by ANOVA) and improved FMD (P, 0.05 by ANOVA). Furthermore, vitamin C improved both SSPG (P < 0.005 by ANOVA) and FMD (P, 0.05 by ANOVA) in nonsmokers with IGT. SSPG, FMD,or TBARS in controls did not change after vitamin C infusion. There was a significant correlation between SSPG and FMD both in smokers and nonsmokerswith IGT, whereas no correlation was observed in controls. In conclusion, both insulin sensitivity and endothelial function were impaired in smokers and nonsmokers with IGT and were improved by vitamin C. Thus increased reactive oxygen species play an important role in the pathogenesis of insulin resistance as well as endothelial dysfunction in smokers and nonsmokers withIGT.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 16:24:15