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Titolo:
Levels of gamma-aminobutyric acid-benzodiazepine receptors in abstinent, alcohol-dependent women: Preliminary findings from an I-123-iomazenil singlephoton emission tomography study
Autore:
Lingford-Hughes, AR; Acton, PD; Gacinovic, S; Boddington, SJA; Costa, DC; Pilowsky, LS; Ell, PJ; Marshall, EJ; Kerwin, RW;
Indirizzi:
Univ Bristol, Sch Med Sci, Psychopharmacol Unit, Bristol BS8 1TD, Avon, England Univ Bristol Bristol Avon England BS8 1TD Bristol BS8 1TD, Avon, England Inst Psychiat, Dept Psychol Med, London SE5 8AF, England Inst Psychiat London England SE5 8AF sychol Med, London SE5 8AF, England Inst Psychiat, Dept Psychol, London SE5 8AF, England Inst Psychiat London England SE5 8AF pt Psychol, London SE5 8AF, England UCL, Sch Med, Inst Nucl Med, London, England UCL London EnglandUCL, Sch Med, Inst Nucl Med, London, England
Titolo Testata:
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
fascicolo: 9, volume: 24, anno: 2000,
pagine: 1449 - 1455
SICI:
0145-6008(200009)24:9<1449:LOGARI>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
FEMALE ALCOHOLICS; GENDER DIFFERENCES; I-123 IOMAZENIL; GABA(A) RECEPTORS; SEX-DIFFERENCES; BRAIN ATROPHY; ETHANOL; METABOLISM; BINDING; SEVERITY;
Keywords:
alcoholism; sex; imaging; GABA-benzodiazepine receptor; human;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Lingford-Hughes, AR Univ Bristol, Sch Med Sci, Psychopharmacol Unit, Univ Walk, Bristol BS8 1TD, Avon, England Univ Bristol Univ Walk Bristol Avon England BS8 1TD nd
Citazione:
A.R. Lingford-Hughes et al., "Levels of gamma-aminobutyric acid-benzodiazepine receptors in abstinent, alcohol-dependent women: Preliminary findings from an I-123-iomazenil singlephoton emission tomography study", ALC CLIN EX, 24(9), 2000, pp. 1449-1455

Abstract

Background: Although alcohol dependence in women is an increasing problem,little is known about the effects of alcohol on the female brain. Evidencefrom a few structural and functional neuroimaging studies suggests that the female brain may be more susceptible than the male brain to the harmful effects of alcohol. However, no in vivo studies of the neuropharmacology of alcohol dependence in women have been carried out. The aim of this preliminary study was to test the hypothesis that alcohol dependence in women is associated with greater reduction in gamma-aminobutyric acid (GABA)-benzodiazepine receptor levels than in men with an equivalent drinking history. Methods: We used single photon emission tomography and I-123-iomazenil to label the central GABA-benzodiazepine receptor and to compare semiquantified levels in 9 abstinent alcohol-dependent and 13 control women. These groups were further compared with equivalent male groups from a previous study. Results: There was a trend toward a reduction in GABA-benzodiazepine receptor levels in alcohol-dependent women, but this did not reach significance. These lower levels were seen primarily in the cerebellum, occipital lobes,and parietal cortex (left > right). This was in marked contrast with the pattern of reduction seen in the previous study of male dependence, where significant reductions were seen primarily in the frontal cortex. Conclusions: Due to the semiquantitative analysis performed and the relatively small number of subjects in this study, which resulted in a nonsignificant trend, we can only comment on the differences in the pattern of lower levels of GABA-benzodiazepine receptors seen in alcohol dependence in men and women. Although we are not able to ascertain whether the female brain ismore susceptible to the effects of alcohol, it appears that alcohol has a differential effect on the central GABA-benzodiazepine receptors in men andwomen. Recent animal evidence supports this hypothesis. Future studies should explore whether other neuropharmacological differences exist between men and women in alcohol dependence that could have implications for pharmacotherapy.

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Documento generato il 21/01/20 alle ore 01:03:18