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Titolo:
Polysomnographic and spectral sleep EEG in primary alcoholics: An interaction between alcohol dependence and African-American ethnicity
Autore:
Irwin, M; Miller, C; Gillin, JC; Demodena, A; Ehlers, CL;
Indirizzi:
Univ Calif San Diego, La Jolla, CA 92161 USA Univ Calif San Diego La Jolla CA USA 92161 Diego, La Jolla, CA 92161 USA San Diego VA Med Ctr, La Jolla, CA 92161 USA San Diego VA Med Ctr La Jolla CA USA 92161 ed Ctr, La Jolla, CA 92161 USA
Titolo Testata:
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
fascicolo: 9, volume: 24, anno: 2000,
pagine: 1376 - 1384
SICI:
0145-6008(200009)24:9<1376:PASSEI>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADMISSION PREDICTS RELAPSE; CHRONIC ETHANOL EXPOSURE; SECONDARY DEPRESSION; WITHDRAWAL; DISORDERS; PATTERNS; RATS; AGE;
Keywords:
alcoholism; sleep; ethnicity; spectral analyses;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Irwin, M Univ Calif San Diego, 3350 La Jolla Village Dr, La Jolla, CA 92161 USA Univ Calif San Diego 3350 La Jolla Village Dr La Jolla CA USA 92161
Citazione:
M. Irwin et al., "Polysomnographic and spectral sleep EEG in primary alcoholics: An interaction between alcohol dependence and African-American ethnicity", ALC CLIN EX, 24(9), 2000, pp. 1376-1384

Abstract

Background: Disturbances of sleep EEG are prominent in alcoholic patients,persist into recovery, and recently have been found to predict those alcoholics who are most likely to relapse. increasing evidence indicates that there are ethnic differences in sleep EEG and that African-Americans may be at elevated risk for disordered sleep. Methods: This study compared polysomnographic and spectral sleep EEG measures in male primary alcoholic inpatients (n = 31) and age-matched comparison controls (n = 31) stratified by African-American and Euro-American ethnicity. Results: African-American alcoholic patients showed more severe sleep abnormalities than Euro-American alcoholics, and the interaction between alcohol dependence and ethnicity uniquely contributed to prolonged sleep latency (p < 0.001), loss of delta sleep (p < 0.001), and short rapid eye movement (REM) latency (p < 0.001). Spectral EEG analyses confirmed polysomnographicfindings of disordered sleep architecture in alcoholics. Compared with controls, alcoholics had lower delta (0.75-4.5 Hz) activity over the whole night (p < 0.05), reductions in mean spectral power (0.75-40 Hz, p < 0.05), and decreases of delta (p < 0.01) and theta (4.5-7.5 Hz,p = 0.05) activity during the first period of non-REM sleep, with African-American alcoholics having the lowest theta of the four groups. Conclusions: In view of the possible connection between relapse and poor sleep and the role of sleep in the maintenance of health, these data have implications for treatment and morbidity outcomes in African-American alcoholics.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 10:33:47