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Titolo:
LOSS OF THE TUMOR-SUPPRESSOR P53 GENE AT THE LIVER-CIRRHOSIS STAGE INJAPANESE PATIENTS WITH HEPATOCELLULAR-CARCINOMA
Autore:
KISHIMOTO Y; SHIOTA G; KAMISAKI Y; WADA K; NAKAMOTO K; YAMAWAKI M; KOTANI M; ITOH T; KAWASAKI H;
Indirizzi:
TOTTORI UNIV,FAC MED,DEPT CLIN PHARMACOL,86 NISHIMACHI YONAGO TOTTORI683 JAPAN TOTTORI UNIV,FAC MED,DEPT INTERNAL MED 2 YONAGO TOTTORI 683 JAPAN
Titolo Testata:
Oncology
fascicolo: 4, volume: 54, anno: 1997,
pagine: 304 - 310
SICI:
0030-2414(1997)54:4<304:LOTTPG>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEPATITIS-B VIRUS; PROTEIN ACCUMULATION; FREQUENT LOSS; OVARIAN-CANCER; CLONAL ORIGIN; LATE EVENT; HETEROZYGOSITY; MUTATIONS; TRANSACTIVATION; ABNORMALITIES;
Keywords:
HEPATOCELLULAR CARCINOMA; LIVER CIRRHOSIS; LOSS OF HETEROZYGOSITY; P53;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
60
Recensione:
Indirizzi per estratti:
Citazione:
Y. Kishimoto et al., "LOSS OF THE TUMOR-SUPPRESSOR P53 GENE AT THE LIVER-CIRRHOSIS STAGE INJAPANESE PATIENTS WITH HEPATOCELLULAR-CARCINOMA", Oncology, 54(4), 1997, pp. 304-310

Abstract

The incidence of p53 gene aberrations is reported to be about 20-50% in hepatocellular carcinomas (HCCs). In most cases, HCC is clinically preceded by liver cirrhosis, but the genetic changes in cirrhosis are not known well. Therefore, we studied the loss of heterozygosity (LOH)of the p53 gene in cirrhotic and neoplastic foci in the livers of patients with HCC. To assess the relationship between the LOH status of the p53 gene in the liver cirrhosis stage and that in HCC, we analyzed the samples microdissected from paraffin-embedded tissues using the polymerase-chain-reaction-based assay. We studied 18 patients with HCC. Fourteen of the 18 cases showed constitutional heterozygosity for the microsatellite markers. In 8 (57%) of the 14 informative cases, LOH was detected in primary HCCs. Among these 8 doubly informative (informative and LOH positive in primary HCC) cases: 5 cases (63%) showed LOH in liver cirrhosis lesions. The pattern of p53 allelic loss in the cirrhotic foci was identical with that in the corresponding tumor. The remaining 6 cases without LOH of the p53 gene in HCC showed no p53 loss in any cirrhotic foci. LOH of the p53 gene may occur before the development of HCC.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 05:41:20