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Titolo:
Diversity of the HIV-1 long terminal repeat following mother-to-child transmission
Autore:
Blackard, JT; Renjifo, B; Chaplin, B; Msamanga, G; Fawzi, W; Essex, M;
Indirizzi:
Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 munol & Infect Dis, Boston, MA 02115 USA Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA Harvard UnivBoston MA USA 02115 bl Hlth, Dept Nutr, Boston, MA 02115 USA Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 th, Dept Epidemiol, Boston, MA 02115 USA Muhimbili Med Ctr, Dept Community Hlth, Dar Es Salaam, Tanzania Muhimbili Med Ctr Dar Es Salaam Tanzania Hlth, Dar Es Salaam, Tanzania
Titolo Testata:
VIROLOGY
fascicolo: 2, volume: 274, anno: 2000,
pagine: 402 - 411
SICI:
0042-6822(20000901)274:2<402:DOTHLT>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; MURINE LEUKEMIA-VIRUS; NF-KAPPA-B; ENVELOPE V3 REGION; INFANT TRANSMISSION; GENITAL SECRETIONS; GENE-EXPRESSION; DISEASE SPECIFICITY; SEQUENCE VARIATION; VIRAL PHENOTYPE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Essex, M Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, 651 Huntington Ave, Boston, MA 02115 USA Harvard Univ 651 Huntington Ave Boston MA USA 02115 MA 02115 USA
Citazione:
J.T. Blackard et al., "Diversity of the HIV-1 long terminal repeat following mother-to-child transmission", VIROLOGY, 274(2), 2000, pp. 402-411

Abstract

A study of the human immunodeficiency virus Type 1 (HIV-1) 5' long terminal repeat (LTR) was performed to determine the extent of variation found within the LTR from 19 mother-infant pairs in Tanzania and to assess whether the LTR is useful in distinguishing maternal sequences that were transmittedto infants. HIV-1 subtypes A, C, and D as well as intersubtype recombinantLTR sequences were detected in mothers and infants. The LTR subtype was 100% concordant between mothers and their infants. Diversity calculations showed a significant reduction in LTR variation in infants compared to their mothers. However, the overall magnitude of LTR variation was less than that found in the env gene from the same individuals. These data suggest a selective constraint active upon the 5' long terminal repeat that is distinct from immune selective pressure(s) directed against HIV-1 structural genes. Detection of maternal LTR variants that were transmitted to infants may yieldimportant information concerning nonstructural determinants of HIV-1 transmission from mother to infant. (C) 2000 Academic Press.

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Documento generato il 04/12/20 alle ore 06:42:22