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Titolo:
Immunogenicity and efficacy of Russian live attenuated and US inactivated influenza vaccines used alone and in combination in nursing home residents
Autore:
Rudenko, LG; Arden, NH; Grigorieva, E; Naychin, A; Rekstin, A; Klimov, AI; Donina, S; Desheva, J; Holman, RC; DeGuzman, A; Cox, NJ; Katz, JM;
Indirizzi:
Ctr Dis Control & Prevent, Influenza Branch, Atlanta, GA 30333 USA Ctr DisControl & Prevent Atlanta GA USA 30333 nch, Atlanta, GA 30333 USA Inst Expt Med, Dept Virol, St Petersburg, Russia Inst Expt Med St Petersburg Russia d, Dept Virol, St Petersburg, Russia Ctr Dis Control & Prevent, Div Viral & Rickettsial Dis, Off Director, Atlanta, GA USA Ctr Dis Control & Prevent Atlanta GA USA , Off Director, Atlanta, GA USA
Titolo Testata:
VACCINE
fascicolo: 2-3, volume: 19, anno: 2000,
pagine: 308 - 318
SICI:
0264-410X(20000915)19:2-3<308:IAEORL>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
A VIRUS-VACCINES; RANDOMIZED CONTROLLED TRIAL; LOCAL ANTIBODY-RESPONSES; CHRONICALLY ILL ADULTS; H3N2 EPIDEMIC; DOUBLE-BLIND; SPLIT-VIRUS; B VACCINE; INTRANASAL; TRIVALENT;
Keywords:
influenza vaccines; clinical studies;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Katz, JM Ctr Dis Control & Prevent, Influenza Branch, 1600 Clifton Rd Mailstop G-16, Atlanta, GA 30333 USA Ctr Dis Control & Prevent 1600 Clifton Rd Mailstop G-16 Atlanta GA USA 30333
Citazione:
L.G. Rudenko et al., "Immunogenicity and efficacy of Russian live attenuated and US inactivated influenza vaccines used alone and in combination in nursing home residents", VACCINE, 19(2-3), 2000, pp. 308-318

Abstract

The immunogenicity and efficacy of Russian live attenuated and US inactivated trivalent influenza vaccines administered alone or in three different combinations were evaluated in a randomized, placebo-controlled, double-blinded study of 614 elderly or chronically ill nursing home residents in St. Petersburg, Russia during the 1996-97 influenza season. Postvaccination serum antibody responses were more frequent among individuals administered the combination vaccines than among those vaccinated with live or inactivated vaccine alone. Only individuals who received live vaccine, alone or in combination with inactivated vaccine. achieved significant postvaccination increases in virus-specific nasal IgA. Efficacy in preventing laboratory-confirmed influenza in vaccinated versus nonvaccinated individuals was 67% (95%CI,36-81%) for recipients of a combination of the vaccines compared with 51% (95%CI, -17-79%) for recipients of live vaccine alone and 50% (95%CI, -26-80%) for recipients of inactivated vaccine alone. These results suggest thatadministration of a combination of influenza vaccines may provide a strategy for improved influenza vaccination of elderly people. Published by Elsevier Science Ltd.

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Documento generato il 06/07/20 alle ore 08:54:54