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Titolo:
Differential requirement of the cytoplasmic subregions of gamma c chain inT cell development and function
Autore:
Tsujino, S; Di Santo, JP; Takaoka, A; McKernan, TL; Noguchi, S; Taya, C; Yonekawa, H; Saito, T; Taniguchi, T; Fujii, H;
Indirizzi:
Univ Tokyo, Grad Sch Med, Dept Immunol, Bunkyo Ku, Tokyo 1130033, Japan Univ Tokyo Tokyo Japan 1130033 Immunol, Bunkyo Ku, Tokyo 1130033, Japan Univ Tokyo, Fac Med, Bunkyo Ku, Tokyo 1130033, Japan Univ Tokyo Tokyo Japan 1130033 Fac Med, Bunkyo Ku, Tokyo 1130033, Japan Tokyo Univ Hosp, Dept Hematol & Oncol, Bunkyo Ku, Tokyo 1138655, Japan Tokyo Univ Hosp Tokyo Japan 1138655 col, Bunkyo Ku, Tokyo 1138655, Japan Inst Pasteur, Unite Cytokines & Dev Lymphoide, F-75724 Paris, France Inst Pasteur Paris France F-75724 & Dev Lymphoide, F-75724 Paris, France Kanagawa Acad Sci & Technol, Meiji Inst Hlth Sci, Biosignal Pathway Project, Kanagawa 2500862, Japan Kanagawa Acad Sci & Technol Kanagawa Japan 2500862 nagawa 2500862, Japan Tokyo Metropolitan Inst Med Sci, Dept Lab Anim Sci, Bunkyo Ku, Tokyo 1138613, Japan Tokyo Metropolitan Inst Med Sci Tokyo Japan 1138613 Tokyo 1138613, Japan Chiba Univ, Sch Med, Ctr Biomed Sci, Div Mol Genet,Chuo Ku, Chiba 2608670,Japan Chiba Univ Chiba Japan 2608670 iv Mol Genet,Chuo Ku, Chiba 2608670,Japan
Titolo Testata:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
fascicolo: 19, volume: 97, anno: 2000,
pagine: 10514 - 10519
SICI:
0027-8424(20000912)97:19<10514:DROTCS>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEVERE COMBINED IMMUNODEFICIENCY; DEFECTIVE LYMPHOID DEVELOPMENT; MEMBRANE-PROXIMAL REGION; RECEPTOR-DEFICIENT MICE; JAK-3 JANUS KINASE; IL-2 RECEPTOR; SIGNAL-TRANSDUCTION; TYROSINE KINASES; TRANSGENIC MICE; LACKING JAK3;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Taniguchi, T Univ Tokyo, Grad Sch Med, Dept Immunol, Bunkyo Ku, Hongo 7-3-1, Tokyo 1130033, Japan Univ Tokyo Hongo 7-3-1 Tokyo Japan 1130033 yo 1130033, Japan
Citazione:
S. Tsujino et al., "Differential requirement of the cytoplasmic subregions of gamma c chain inT cell development and function", P NAS US, 97(19), 2000, pp. 10514-10519

Abstract

The common cytokine receptor gamma chain (gamma c), a shared component of the receptors for IL-2, IL-4, IL-7, IL-9, and IL-15, is critical for the development and function of lymphocytes. The cytoplasmic domain of gamma c consists of 85 aa, in which the carboxyl-terminal 48 aa are essential for itsinteraction with and activation of the Janus kinase, Jak3. Evidence has been provided that Jak3-independent signals might be transmitted via the residual membrane-proximal region; however, its role in vivo remains totally unknown. In the present study, we expressed mutant forms of gamma c, which lack either most of the cytoplasmic domain or only the membrane-distal Jak3-binding region, on a gamma c null background. We demonstrate that, unlike gamma c or Jak3 null mice, expression of the latter, but not the former mutant, restores T lymphopoiesis in vivo, accompanied by strong expression of Bcl-2. On the other hand, the in vitro functions of the restored T cells still remained impaired. These results not only reveal the hitherto unknown role of the gamma c membrane-proximal region, but also suggest the differential requirement of the cytoplasmic subregions of gamma c in T cell development and function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/10/20 alle ore 08:07:37