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Titolo:
Identification of diverse nerve growth factor-regulated genes by serial analysis of gene expression (SAGE) profiling
Autore:
Angelastro, JM; Klimaschewski, L; Tang, S; Vitolo, OV; Weissman, TA; Donlin, LT; Shelanski, ML; Greene, LA;
Indirizzi:
Columbia Univ, Coll Phys & Surg, Ctr Neurobiol & Behav, Dept Pathol, New York, NY 10032 USA Columbia Univ New York NY USA 10032 , Dept Pathol, New York, NY 10032 USA Columbia Univ, Coll Phys & Surg, Taub Inst, New York, NY 10032 USA Columbia Univ New York NY USA 10032 rg, Taub Inst, New York, NY 10032 USA
Titolo Testata:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
fascicolo: 19, volume: 97, anno: 2000,
pagine: 10424 - 10429
SICI:
0027-8424(20000912)97:19<10424:IODNGF>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
PC12 CELLS; MESSENGER-RNAS; NEUROTROPHIC FACTORS; BINDING PROTEIN; CLONING; SEQUENCE; COMPLEX; FAMILY; DIFFERENTIATION; REPLICATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Greene, LA Columbia Univ, Coll Phys & Surg, Ctr Neurobiol & Behav, Dept Pathol, 630 W168th St, New York, NY 10032 USA Columbia Univ 630 W 168th St New York NY USA 10032 NY 10032 USA
Citazione:
J.M. Angelastro et al., "Identification of diverse nerve growth factor-regulated genes by serial analysis of gene expression (SAGE) profiling", P NAS US, 97(19), 2000, pp. 10424-10429

Abstract

Neurotrophic factors such as nerve growth factor (NGF) promote a wide variety of responses in neurons, including differentiation. survival, plasticity, and repair. Such actions often require changes in gene expression. To identify the regulated genes and thereby to more fully understand the NGF mechanism, we carried out serial analysis of gene expression (SAGE) profiling of transcripts derived from rat PC12 cells before and after NGF-promoted neuronal differentiation. Multiple criteria supported the reliability of the profile. Approximately 157,000 SAGE tags were analyzed, representing at least 21,000 unique transcripts. Of these, nearly 800 were regulated by 6-foldor more in response to NGF. Approximately 150 of the regulated transcriptshave been matched to named genes, the majority of which were not previously known to be NGF-responsive. Functional categorization of the regulated genes provides insight into the complex, integrated mechanism by which NGF promotes its multiple actions. It is anticipated that as genomic sequence information accrues the data derived here will continue to provide informationabout neurotrophic factor mechanisms.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/05/20 alle ore 20:44:22