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Titolo:
THE INTERACTIONS OF APC, E-CADHERIN AND BETA-CATENIN IN TUMOR-DEVELOPMENT AND PROGRESSION
Autore:
ILYAS M; TOMLINSON IPM;
Indirizzi:
JOHN RADCLIFFE HOSP,INST MOL MED,IMPERIAL CANC RES FUND,CANC GENET & IMMUNOL LAB OXFORD OX3 9DU ENGLAND ROYAL MARSDEN HOSP,ICR,HADDOW LABS SUTTON SH2 5NG SURREY ENGLAND
Titolo Testata:
Journal of pathology
fascicolo: 2, volume: 182, anno: 1997,
pagine: 128 - 137
SICI:
0022-3417(1997)182:2<128:TIOAEA>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
MCC GENETIC-LOCI; FAMILIAL ADENOMATOUS POLYPOSIS; EPIDERMAL GROWTH-FACTOR; HUMAN PROSTATE-CANCER; CELL-CELL-ADHESION; ALPHA-CATENIN; GASTRIC-CANCER; COLORECTAL TUMORIGENESIS; TYROSINE PHOSPHORYLATION; SIGNAL-TRANSDUCTION;
Keywords:
ADENOMATOUS POLYPOSIS COLI (APC); BETA-CATENIN; E-CADHERIN; TUMOR INITIATION; TUMOR PROGRESSION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
83
Recensione:
Indirizzi per estratti:
Citazione:
M. Ilyas e I.P.M. Tomlinson, "THE INTERACTIONS OF APC, E-CADHERIN AND BETA-CATENIN IN TUMOR-DEVELOPMENT AND PROGRESSION", Journal of pathology, 182(2), 1997, pp. 128-137

Abstract

Much progress has been made in identifying genes mutated during the development of colorectal carcinoma. Mutation of the APC gene in particular appears to be fundamental for colorectal tumour initiation. In contrast, loss of expression of E-cadherin appears to be a late event, which may be important in the development of invasion. Recent clarification of the function of APC, however, has shown that it exists in equilibrium with beta-catenin and E-cadherin. This review discusses the functions of these molecules, their interactions, and how APC mutations may alter the equilibrium with beta-catenin and E-cadherin. It is argued that these changes cause aberrant architectural development of tissue, which results in loss of growth control. It is this escape from growth control, rather than acquisition of cell-autonomous growth which results in the initial development of adenomas. The role of the E-cadherin-catenin unit in colorectal tumour invasion is discussed and the evidence is reviewed for the involvement of APC and E-cadherin in tumours arising from non-intestinal epithelia. (C) 1997 by John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 08:21:28