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Titolo:
Adenovirus and marrow transplantation in children
Autore:
Foster, CB; Choi, EH; Chanock, SJ;
Indirizzi:
NCI, Immunocompromised Host Sect, Pediat Oncol Branch, Ctr Adv Technol,NIH, Gaithersburg, MD 20877 USA NCI Gaithersburg MD USA 20877 Adv Technol,NIH, Gaithersburg, MD 20877 USA
Titolo Testata:
PEDIATRIC PATHOLOGY & MOLECULAR MEDICINE
fascicolo: 2-3, volume: 19, anno: 2000,
pagine: 97 - 114
SICI:
1522-7952(200003/06)19:2-3<97:AAMTIC>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRAVENOUS RIBAVIRIN THERAPY; SEVERE COMBINED IMMUNODEFICIENCY; INDUCED HEMORRHAGIC CYSTITIS; POLYMERASE CHAIN-REACTION; ACUTE RESPIRATORY-DISEASE; IN-SITU HYBRIDIZATION; VIRAL-INFECTIONS; IMMUNOCOMPROMISED PATIENTS; PULMONARY INFECTIONS; DIGEORGE-SYNDROME;
Keywords:
immunocompromised host; serotype; supportive care; viral infection;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
99
Recensione:
Indirizzi per estratti:
Indirizzo: Chanock, SJ NCI, Immunocompromised Host Sect, Pediat Oncol Branch, Ctr AdvTechnol,NIH, Gaithersburg, MD 20877 USA NCI Gaithersburg MD USA 20877 NIH, Gaithersburg, MD 20877 USA
Citazione:
C.B. Foster et al., "Adenovirus and marrow transplantation in children", PEDIAT PATH, 19(2-3), 2000, pp. 97-114

Abstract

Adenovirus disease is a major cause of morbidity and mortality among recipients of marrow trans-plants. Recent advances have contributed to a finer understanding of the biological basis for viral persistence in the normal host as well as disseminated disease in the immunocompromised patient. However, these insights have not yielded new, effective therapeutic interventions. Currently, there are no proven antiviral therapies available for treatingadenoviral disease. Anecdotal reports have indicated that combinations of ribavirin, intravenous immunoglobulin, and donor T cells are efficacious incases with limited infection. We anticipate that the incidence of adenoviral infections in marrow transplant recipients will continue to increase because the pool of transplant recipients continues to enlarge and more immunosuppressive preparative regimens, including T-cell depletion, are more commonly used. This review summarizes the clinical manifestations of adenovirusin the bone marrow transplant population including such common complications as hemorrhagic cystitis and rarer manifestations of disseminated infection, such as nephritis, gastroenteritis, pneumonia, hepatitis, pancreatitis,and encephalitis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 20:55:43