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Titolo:
Mathematical modelling of the within-host dynamics of Plasmodium falciparum
Autore:
Hoshen, MB; Heinrich, R; Stein, WD; Ginsburg, H;
Indirizzi:
Hebrew Univ Jerusalem, Inst Life Sci, Dept Biol Chem, IL-91904 Jerusalem, Israel Hebrew Univ Jerusalem Jerusalem Israel IL-91904 -91904 Jerusalem, Israel Humboldt Univ, Inst Biol, D-10115 Berlin, Germany Humboldt Univ Berlin Germany D-10115 Inst Biol, D-10115 Berlin, Germany
Titolo Testata:
PARASITOLOGY
, volume: 121, anno: 2000,
parte:, 3
pagine: 227 - 235
SICI:
0031-1820(200009)121:<227:MMOTWD>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-RATES; IN-VIVO; MALARIA; PARASITES; ERRORS; LEAD;
Keywords:
Plasmodium falciparum; mathematical model; within-host; synchrony;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Hoshen, MB Hebrew Univ Jerusalem, Inst Life Sci, Dept Biol Chem, IL-91904 Jerusalem, Israel Hebrew Univ Jerusalem Jerusalem Israel IL-91904 salem, Israel
Citazione:
M.B. Hoshen et al., "Mathematical modelling of the within-host dynamics of Plasmodium falciparum", PARASITOL, 121, 2000, pp. 227-235

Abstract

The development of malaria due to Plasmodium falciparum is a complex, multi-stage process. It is usually characterized by an exponential growth in the number of parasite-infected erythrocytes, followed by marked oscillationsin this number with a period of 48 h, which are eventually dampened. This course of events has been the subject of various mathematical models. In this paper we propose a new mathematical model for the in-host asexual erythrocytic development of P. falciparum malaria. Synchronicity of the infectionis shown to be an inherent feature of infection, irrespective of the duration of merozoite release from the liver. It will, therefore, cause periodicsymptoms, as known in malaria patients. We also simulate the effects of aninduced host immune response and show how the level of immunity affects the development of disease. The simulations fit well with the clinical observations. We show how infection can become asynchronous and discuss the effect of desynchronization on the circulating and total parasitaemia and demonstrate that synchronized broods will show parasitaemia fluctuations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 21:49:23