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Titolo:
Effects of topical clonidine on prostaglandin-E-2-induced aqueous flare elevation in pigmented rabbits
Autore:
Watanabe, K; Hayasaka, S; Hiraki, S; Matsumoto, M; Kadoi, C; Nagaki, Y; Hayasaka, Y;
Indirizzi:
Toyama Med & Pharmaceut Univ, Dept Ophthalmol, Toyama 9300194, Japan Toyama Med & Pharmaceut Univ Toyama Japan 9300194 Toyama 9300194, Japan
Titolo Testata:
OPHTHALMIC RESEARCH
fascicolo: 5, volume: 32, anno: 2000,
pagine: 210 - 214
SICI:
0030-3747(200009/10)32:5<210:EOTCOP>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRAOCULAR-PRESSURE; APRACLONIDINE;
Keywords:
aqueous flare elevation; clonidine; pigmented rabbits; prostaglandin E-2; yohimbine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Watanabe, K Toyama Med & Pharmaceut Univ, Dept Ophthalmol, 2630 Sugitani, Toyama 9300194, Japan Toyama Med & Pharmaceut Univ 2630 Sugitani Toyama Japan 9300194
Citazione:
K. Watanabe et al., "Effects of topical clonidine on prostaglandin-E-2-induced aqueous flare elevation in pigmented rabbits", OPHTHAL RES, 32(5), 2000, pp. 210-214

Abstract

We evaluated the role of topical clonidine on experimental ocular inflammation. Transcorneal diffusion of prostaglandin (PG) E-2,E- 7.09 x 10(-2) mmol/l, with the use of a glass cylinder was employed to produce aqueous flareelevation in pigmented rabbits. Clonidine was topically administered and yohimbine was injected intravenously. Aqueous flare was measured with a laserflare cell meter. Topical instillation of 0.25% clonidine inhibited 89% ofPGE(2)-induced aqueous flare elevation. Instillation of clonidine at 60 or30 min before and 10 min after PGE(2) inhibited flare significantly. Pretreatment with intravenous yohimbine decreased the clonidine-induced inhibition of the flare elevation in a dose-dependent manner. It is possible that the anti-inflammatory action of topical clonidine may be mediated partly by alpha(2)-receptors. Copyright (C) 2000 S.Karger AG,Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 16:02:53