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Titolo:
Derivation of [C-11]WAY-100635 binding parameters with reference tissue models: Effect of violations of model assumptions
Autore:
Slifstein, M; Parsey, RV; Laruelle, M;
Indirizzi:
New York State Psychiat Inst, Dept Neurosci, Div Brain Imaging, New York, NY 10032 USA New York State Psychiat Inst New York NY USA 10032 New York, NY 10032 USA Columbia Univ, Coll Phys & Surg, Dept Psychiat, New York, NY USA Columbia Univ New York NY USA ys & Surg, Dept Psychiat, New York, NY USA Columbia Univ, Coll Phys & Surg, Dept Radiol, New York, NY USA Columbia Univ New York NY USA Phys & Surg, Dept Radiol, New York, NY USA
Titolo Testata:
NUCLEAR MEDICINE AND BIOLOGY
fascicolo: 5, volume: 27, anno: 2000,
pagine: 487 - 492
SICI:
0969-8051(200007)27:5<487:DO[BPW>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; RECEPTOR-BINDING; HUMAN-BRAIN; PET; SPECT; QUANTITATION;
Keywords:
positron emission tomography; [C-11]WAY 100635; 5-HT1A receptors; reference tissue model;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Slifstein, M New York State Psychiat Inst, Dept Neurosci, Div Brain Imaging, 1051 Riverside Dr,Unit 42, New York, NY 10032 USA New York State Psychiat Inst 1051 Riverside Dr,Unit 42 New York NY USA 10032
Citazione:
M. Slifstein et al., "Derivation of [C-11]WAY-100635 binding parameters with reference tissue models: Effect of violations of model assumptions", NUCL MED BI, 27(5), 2000, pp. 487-492

Abstract

In several positron-emission tomography studies of human subjects, analyses of data from the 5-hydroxytryptamine(1A) (5-HT1A) receptor radioligand, [C-11]WAY-100635 {[carbonyl-C-11]N-(2-(4-methoxy-phenyl)-1-piperazin-1-yl)ethyl)-N-(2-pyridyl)cyclohexanecarboxamide} have shown a discrepancy between the outcome measure k(3)/k(4) (binding potential normalized to cerebellum) as estimated by the simplified reference region method and results obtainedby conventional kinetic modeling with an arterial input function. The reference region method has yielded results that are lower than the conventional approach, with the relative underestimation appearing to be an increasingfunction of k(3)/k(4). We performed simulations on idealized data to identify the source of the discrepancy, Both the simplified reference tissue model (SRTM) and the original full reference tissue model (FRTM) were tested to determine (a) if the error in estimated k(3)/k(4) is dependent on the blood flow in the region of interest relative to the blood flow in the region of reference (R-1) and on the receptor density in the region of interest (true k(3)/k(4)), and (b) which violation of the reference model assumptions were responsible for this effect. FRTM returned parameter estimates that were independent and accurate if the reference region was constructed precisely as a one-tissue compartment model. SRTM overestimated k(3)/k(4) when thereference region was constructed as a one-tissue compartment model and underestimated k(3)/k(4) when the reference region was constructed as a two-tissue compartment model (which is the case for [C-11]WAY-100635). In both cases, the magnitude of the error in k(3)/k(4) returned by SRTM was dependenton true R-1 and true k(3)/k(4). In conclusion, the SRTM is associated witha bias in the derivation of k(3)/k(4) that is not a simple scaling factor. This magnitude of these errors should be carefully evaluated for each new radioligand. NUCL MED BIOL 27;5:487-492, 2000. (C) 2000 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 13:53:31