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Titolo:
Quantification of [carbonyl-C-11]WAY-100635 binding: Considerations on thecerebellum
Autore:
Oikonen, V; Allonen, T; Nagren, K; Kajander, J; Hietala, J;
Indirizzi:
Univ Turku, Turku PET Ctr, FIN-20521 Turku, Finland Univ Turku Turku Finland FIN-20521 rku PET Ctr, FIN-20521 Turku, Finland Univ Turku, Dept Pharmacol & Clin Pharmacol, FIN-20521 Turku, Finland UnivTurku Turku Finland FIN-20521 n Pharmacol, FIN-20521 Turku, Finland Univ Turku, Cent Hosp, Dept Psychiat, FIN-20521 Turku, Finland Univ TurkuTurku Finland FIN-20521 pt Psychiat, FIN-20521 Turku, Finland
Titolo Testata:
NUCLEAR MEDICINE AND BIOLOGY
fascicolo: 5, volume: 27, anno: 2000,
pagine: 483 - 486
SICI:
0969-8051(200007)27:5<483:QO[BCO>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
5-HT1A RECEPTORS; PET; LOCALIZATION;
Keywords:
WAY-100635; serotonin 5-HT1A receptor; PET; cerebellum;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
11
Recensione:
Indirizzi per estratti:
Indirizzo: Oikonen, V Univ Turku, Turku PET Ctr, POB 52, FIN-20521 Turku, Finland Univ Turku POB 52 Turku Finland FIN-20521 20521 Turku, Finland
Citazione:
V. Oikonen et al., "Quantification of [carbonyl-C-11]WAY-100635 binding: Considerations on thecerebellum", NUCL MED BI, 27(5), 2000, pp. 483-486

Abstract

The specific binding of [carbonyl-C-11]WAY-100635 to 5-hydroxytryptamine(1A) receptors was quantitated using different kinetic models. Ten healthy subjects were studied using a GE Advance PET scanner. We suggest that tissue heterogeneity explains part of the nonspecific binding seen in cerebellum, which leads to an underestimation of binding potential with reference tissue methods. The nonlinear three-compartmental model with metabolite-corrected plasma input provides accurate estimates of receptor binding because of the favorable kinetics of tracer in the brain and circulation. NUCL MED BIOL27;5:483-486, 2000. (C) 2000 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 00:39:50