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Titolo:
Central 5-HT1A receptors: Regional distribution and functional characteristics
Autore:
Lanfumey, L; Hamon, M;
Indirizzi:
Fac Med Pitie Salpetriere, INSERM, U288, F-75634 Paris 13, France Fac Med Pitie Salpetriere Paris France 13 U288, F-75634 Paris 13, France
Titolo Testata:
NUCLEAR MEDICINE AND BIOLOGY
fascicolo: 5, volume: 27, anno: 2000,
pagine: 429 - 435
SICI:
0969-8051(200007)27:5<429:C5RRDA>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
DORSAL RAPHE NUCLEUS; IN-VIVO BINDING; RAT-BRAIN; INVITRO BINDING; MESSENGER-RNA; SITES; VITRO; AUTORECEPTORS; RADIOLIGAND; WAY-100635;
Keywords:
5-hydroxytryptamine; receptors; raphe; hippocampus; transduction; depression;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Lanfumey, L CHU Pitie Salpetriere, INSERM, U288, 91 Blvd Hop, F-75634 Paris 13, France CHU Pitie Salpetriere 91 Blvd Hop Paris France 13 13, France
Citazione:
L. Lanfumey e M. Hamon, "Central 5-HT1A receptors: Regional distribution and functional characteristics", NUCL MED BI, 27(5), 2000, pp. 429-435

Abstract

Among the multiple receptors for serotonin identified to date, the 5-hydroxytryptamine (5-HT)(1A) type is among the best known because selective ligands have been available for more than 15 years. Radioactive derivatives allowed the demonstration of the presence of 5-HT1A binding sites mainly in the limbic areas and the raphe nuclei in the brain, where they correspond to postsynaptic receptors and "presynaptic" autoreceptors, respectively. This review article summarizes key data on the molecular, pharmacological, and differential functional properties of pre- versus postsynaptic 5-HT1A receptors. NUCL MED BIOL 27;5:429-435, 2000. (C) 2000 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 10:04:55