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Titolo:
Visualisation of AMPA binding sites in the brain of mice lacking the adenosine A(2a) receptor
Autore:
Snell, BJ; Short, JL; Drago, J; Ledent, C; Lawrence, AJ;
Indirizzi:
Monash Univ, Fac Med, Dept Pharmacol, Clayton, Vic 3800, Australia Monash Univ Clayton Vic Australia 3800 acol, Clayton, Vic 3800, Australia Monash Med Ctr, Dept Med, Clayton, Vic 3168, Australia Monash Med Ctr Clayton Vic Australia 3168 d, Clayton, Vic 3168, Australia Free Univ Brussels, Fac Med, Inst Rech Interdisciplinaire, Brussels, Belgium Free Univ Brussels Brussels Belgium terdisciplinaire, Brussels, Belgium
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 2, volume: 291, anno: 2000,
pagine: 97 - 100
SICI:
0304-3940(20000915)291:2<97:VOABSI>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEUS-TRACTUS-SOLITARIUS; CENTRAL-NERVOUS-SYSTEM; CARDIOVASCULAR-RESPONSES; GLUTAMATE RECEPTORS; HYPERTENSIVE RATS; BLOOD-PRESSURE; AREA POSTREMA; STEM; MODULATION;
Keywords:
autonomic nervous system; receptor autoradiography; glutamate; AMPA receptors; adenosine receptors; (S)-[H-3]-5-fluorowillardiine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Lawrence, AJ Monash Univ, Fac Med, Dept Pharmacol, POB 13E, Clayton, Vic 3800, Australia Monash Univ POB 13E Clayton Vic Australia 3800 800, Australia
Citazione:
B.J. Snell et al., "Visualisation of AMPA binding sites in the brain of mice lacking the adenosine A(2a) receptor", NEUROSCI L, 291(2), 2000, pp. 97-100

Abstract

Adenosine A(2a) receptor knockout mice (A(2a)R k/o) have been characterised as hypertensive, aggressive, anxious and hypoalgesic [12]. Thus, the present study was designed to investigate markers of glutamatergic transmissionin specific brain nuclei associated with autonomic regulation. Visualisation of alpha-amino-3-hydroxy-5-methylisoxasole-4-propionic acid binding sites in the brains of A(2a)R k/o mice was achieved by utilising quantitative receptor autoradiography with (S)[H-3]-5-fluorowillardiine ([H-3]FW:10 nM) on slide-mounted sections of mouse-brain. [H-3]FW binding significantly increased in the nucleus tractus solitarius and area postrema of A(2a)R k/o mice compared with wildtype CD-1 mice. In other autonomic nuclei examined, binding was unchanged between wildtype and knockout mice. The present study suggests that glutamatergic neurotransmission within certain neural pathways involved in autonomic and motor control is altered in the brains of A(2a)R k/o mice. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 04:30:46