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Titolo:
Nitrergic neurons make synapses on dual-input dendritic spines of neurons in the cerebral cortex and the striatum of the rat: Implication for a postsynaptic action of nitric oxide
Autore:
Sancesario, G; Morello, M; Reiner, A; Giacomini, P; Massa, R; Schoen, S; Bernardi, G;
Indirizzi:
Univ Roma Tor Vergata, Dept Neurosci, I-00133 Rome, Italy Univ Roma Tor Vergata Rome Italy I-00133 t Neurosci, I-00133 Rome, Italy Univ Tennessee, Dept Anat & Neurobiol, Memphis, TN USA Univ Tennessee Memphis TN USA ee, Dept Anat & Neurobiol, Memphis, TN USA Univ La Sapienza, Dept Neurosci, Rome, Italy Univ La Sapienza Rome Italy niv La Sapienza, Dept Neurosci, Rome, Italy Univ Aachen, Sch Med, Dept Neurol, D-5100 Aachen, Germany Univ Aachen Aachen Germany D-5100 d, Dept Neurol, D-5100 Aachen, Germany IRCCS S Lucia, Rome, Italy IRCCS S Lucia Rome ItalyIRCCS S Lucia, Rome, Italy
Titolo Testata:
NEUROSCIENCE
fascicolo: 4, volume: 99, anno: 2000,
pagine: 627 - 642
SICI:
0306-4522(2000)99:4<627:NNMSOD>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYPEPTIDE (APP)-LIKE IMMUNOREACTIVITIES; PARVALBUMIN-CONTAINING NEURONS; NADPH-DIAPHORASE; NEUROPEPTIDE-Y; SUBCELLULAR-LOCALIZATION; TYROSINE-HYDROXYLASE; BASAL GANGLIA; ULTRASTRUCTURAL-LOCALIZATION; CYTOCHROME-OXIDASE; NUCLEUS-ACCUMBENS;
Keywords:
nitric oxide synthase; axon terminals; anterograde messenger; axodendritic interaction; immunoelectron microscopy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
62
Recensione:
Indirizzi per estratti:
Indirizzo: Sancesario, G Univ Roma Tor Vergata, Dept Neurosci, Via Tor Vergata 135, I-00133 Rome, Italy Univ Roma Tor Vergata Via Tor Vergata 135 Rome Italy I-00133
Citazione:
G. Sancesario et al., "Nitrergic neurons make synapses on dual-input dendritic spines of neurons in the cerebral cortex and the striatum of the rat: Implication for a postsynaptic action of nitric oxide", NEUROSCIENC, 99(4), 2000, pp. 627-642

Abstract

Pre-embedding electron microscopic immunocytochemistry was used to examinethe ultrastructure of neurons containing nitric oxide synthase and to evaluate their synaptic relationships with target neurons in the striatum and sensorimotor cerebral sorter. Intense nitric oxide synthase immunoreactivitywas found by light and electron microscopy in a type of aspiny neuron scattered in these two regions. The intensity of the labeling was uniform in the soma, dendrites and axon terminals of these neurons. In both forebrain regions, nitric oxide synthase-immunoreactive neurons received synaptic contacts from unlabeled terminals, which were mostly apposed to small-caliber dendrites. The unlabeled symmetric contacts were generally about four times as abundant as the unlabeled asymmetric contacts on the nitric oxide synthase-immunoreactive neurons. Terminals labeled for nitric oxide synthase were filled with synaptic vesicles and were observed to contact unlabeled neurons. Only 54% tin the cerebral cortex) and 44.3% tin the striatum) of the nitric oxide synthase-immunoreactive terminals making apposition with the target structures were observed to form synaptic membrane specializations within the plane of the randomly sampled sections. The most common targets of nitric oxide synthase-immunoreactive terminals were thin dendritic shafts (54% Of the immunoreactive terminals in the cortex and 75.7% of the immunoreactive terminals in the striatum), while dendritic spines were a common secondary target (42% of the immunoreactive terminals in the cortex and 20.6% ofthe immunoreactive terminals in the striatum). The spines contacted by nitric oxide synthase-immunoreactive terminals typically also received an asymmetric synaptic contact from an unlabeled axon terminal. These findings suggest that: (i) nitric oxide synthase-immunoreactive neurons in the cortex and striatum preponderantly receive inhibitory input; (ii) nitric oxide synthase-containing terminals commonly make synaptic contactwith target structures in the cortex and striatum; (iii) spines targeted by nitric oxide synthase-containing terminals in the cortex and striatum commonly receive an asymmetric contact as well, which may provide a basis for a synaptic interaction of nitric oxide with excitatory input to individual spines. (C) 2000 IBRO. Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 17:22:02