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Titolo:
Vascular and parenchymal A beta deposition in the aging dog: correlation with behavior
Autore:
Colle, MA; Hauw, JJ; Crespeau, F; Uchihara, T; Akiyama, H; Checler, F; Pageat, P; Duykaerts, C;
Indirizzi:
Hop La Pitie Salpetriere, Lab Neuropathol R Escourolle, F-75651 Paris, France Hop La Pitie Salpetriere Paris France F-75651 lle, F-75651 Paris, France Hop La Pitie Salpetriere, Assoc Claude Bernard, Lab Neuropathol R Escourolle, F-75651 Paris 13, France Hop La Pitie Salpetriere Paris France 13 rolle, F-75651 Paris 13, France Ecole Natl Vet Alfort, Serv Anatomopathol, Maisons Alfort, France Ecole Natl Vet Alfort Maisons Alfort France hol, Maisons Alfort, France Inst Psychiat, Tokyo, Japan Inst Psychiat Tokyo JapanInst Psychiat, Tokyo, Japan Inst Pharmacol Mol & Cellulaire, Valbonne, France Inst Pharmacol Mol & Cellulaire Valbonne France laire, Valbonne, France Pherosynthese, Apt, France Pherosynthese Apt FrancePherosynthese, Apt, France
Titolo Testata:
NEUROBIOLOGY OF AGING
fascicolo: 5, volume: 21, anno: 2000,
pagine: 695 - 704
SICI:
0197-4580(200009/10)21:5<695:VAPABD>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALZHEIMERS-DISEASE; SENILE PLAQUES; AGED DOGS; INTELLECTUAL STATUS; NEUROFIBRILLARY TANGLES; AMYLOID ACCUMULATION; PREAMYLOID DEPOSITS; NEURITIC PLAQUES; DOWNS-SYNDROME; POLAR BEAR;
Keywords:
A beta peptide; canine; cognitive evaluation; Alzheimer's disease; senile plaques;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Duykaerts, C Hop La Pitie Salpetriere, Lab Neuropathol R Escourolle, F-75651 Paris, France Hop La Pitie Salpetriere Paris France F-75651 Paris, France
Citazione:
M.A. Colle et al., "Vascular and parenchymal A beta deposition in the aging dog: correlation with behavior", NEUROBIOL A, 21(5), 2000, pp. 695-704

Abstract

The behavior of 25 dogs was indirectly assessed by a formal questionnaire (evaluation of Age-Related Cognitive and Affective Disorders-ARCAD), filledout by the owner. The density of diffuse and vascular deposits was evaluated using four anti-A beta peptide antibodies, in four temporal areas. Parenchymal, diffuse deposits of A beta 42 peptide were found in all aged animals but one. They were Congo red negative and were not immunostained by the anti-A beta 40 antibody, contrary to the vascular deposits. The densities ofvascular and parenchymal deposits were not correlated. The ARCAD score wascorrelated with age, density of A beta parenchymal and vascular deposits, and with the number of areas containing deposits (extension index). Multivariate analysis showed that the age and the extension index explained most of the variance. Congo red positivity (indicating that the A beta peptide has the characteristics of an amyloid substance) is limited in the dog to thevascular wall and is associated, as in man, with the deposition of the A beta 1-40 isoform. Parenchymal A beta deposition seems to be a common correlate of behavioral problems in aging dogs. (C) 2000 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 00:29:26