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Titolo:
Age-related dopamine D2/D3 receptor loss in extrastriatal regions of the human brain
Autore:
Kaasinen, V; Vilkman, H; Hietala, J; Nagren, K; Helenius, H; Olsson, H; Farde, L; Rinne, JO;
Indirizzi:
Turku Univ, Dept Neurol, Turku, Finland Turku Univ Turku FinlandTurku Univ, Dept Neurol, Turku, Finland Univ Turku, Dept Pharmacol, Turku, Finland Univ Turku Turku FinlandUniv Turku, Dept Pharmacol, Turku, Finland Univ Turku, Dept Psychiat, Turku, Finland Univ Turku Turku FinlandUniv Turku, Dept Psychiat, Turku, Finland Turku PET Ctr, Turku, Finland Turku PET Ctr Turku FinlandTurku PET Ctr, Turku, Finland Univ Turku, Dept Biostat, Turku, Finland Univ Turku Turku FinlandUniv Turku, Dept Biostat, Turku, Finland Karolinska Hosp, Dept Clin Neurosci, S-10401 Stockholm, Sweden Karolinska Hosp Stockholm Sweden S-10401 osci, S-10401 Stockholm, Sweden
Titolo Testata:
NEUROBIOLOGY OF AGING
fascicolo: 5, volume: 21, anno: 2000,
pagine: 683 - 688
SICI:
0197-4580(200009/10)21:5<683:ADDRLI>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; LIVING HUMAN-BRAIN; AGING HUMAN-BRAIN; C-11 RACLOPRIDE; D-2 RECEPTOR; SEX-DIFFERENCES; D2 RECEPTORS; BINDING; PET; DYSFUNCTION;
Keywords:
extrastriatal; dopamine D2-like receptors; aging; [C-11]FLB 457;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Kaasinen, V Turku Univ, Dept Neurol, Turku, Finland Turku Univ Turku Finland Univ, Dept Neurol, Turku, Finland
Citazione:
V. Kaasinen et al., "Age-related dopamine D2/D3 receptor loss in extrastriatal regions of the human brain", NEUROBIOL A, 21(5), 2000, pp. 683-688

Abstract

Loss of dopamine D2-like receptors in the striatum has been associated with both normal human aging and impairment of cognitive and motor functions in the elderly. To investigate whether there are age-associated changes in dopamine D2 and D3 receptor subtypes (D2/3Rs) outside the striatum, a D2/3R selective high-affinity radioligand [C-11]FLB 457 was used in positron emission tomography (PET) examinations for 24 normal healthy male subjects (agerange 19-74 years). Significant age-related declines of D2/3Rs were detected in all the brain regions studied: the anterior cingulate cortex (declineof 13% per increase of a decade in age, P < 0.001), the frontal cortex (11%, P < 0.001), the lateral temporal cortex (10%, P < 0.001), the hippocampus (10%, P < 0.01), the medial temporal cortex (9%, P < 0.001), the amygdala(7%, P < 0,01), the medial thalamus (6%, P < 0.001) and the lateral thalamus (5%, P < 0.01). The rate of D2/3R decline was significantly faster in the frontal cortex as compared to the medial temporal cortex (P < 0.05, Bonferroni corrected) and as compared to the medial thalamus (P < 0.05, Bonferroni corrected). These results indicate that the previously demonstrated age-related decline in striatal dopamine D2 receptors extends to several extrastriatal regions in normal human males. Further, the rate of D2/3R decline may be faster in the frontal cortex as compared to the temporal and thalamicregions. (C) 2000 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 14:27:02