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Titolo:
Neurodegenerative stimuli induce persistent ADF/cofilin-actin rods that disrupt distal neurite function
Autore:
Minamide, LS; Striegl, AM; Boyle, JA; Meberg, PJ; Bamburg, JR;
Indirizzi:
Colorado State Univ, Dept Biochem & Mol Biol, Ft Collins, CO 80523 USA Colorado State Univ Ft Collins CO USA 80523 iol, Ft Collins, CO 80523 USA Colorado State Univ, Mol Cellular & Integrat Neurosci Program, Ft Collins,CO 80523 USA Colorado State Univ Ft Collins CO USA 80523 gram, Ft Collins,CO 80523 USA
Titolo Testata:
NATURE CELL BIOLOGY
fascicolo: 9, volume: 2, anno: 2000,
pagine: 628 - 636
SICI:
1465-7392(200009)2:9<628:NSIPAR>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPOLYMERIZING FACTOR; OXIDATIVE STRESS; HIPPOCAMPAL-NEURONS; ALZHEIMERS-DISEASE; COFILIN PHOSPHORYLATION; BINDING-PROTEINS; HIRANO BODIES; AGED RATS; BRAIN; DYNAMICS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Bamburg, JR Colorado State Univ, Dept Biochem & Mol Biol, Ft Collins, CO 80523 USA Colorado State Univ Ft Collins CO USA 80523 ins, CO 80523 USA
Citazione:
L.S. Minamide et al., "Neurodegenerative stimuli induce persistent ADF/cofilin-actin rods that disrupt distal neurite function", NAT CELL BI, 2(9), 2000, pp. 628-636

Abstract

Inclusions containing actin-depolymerizing factor (ADF) and cofilin, abundant proteins in adult human brain, are prominent in hippocampal and cortical neurites of the post-mortem brains of Alzheimer's patients, especially inneurites contacting amyloid deposits. The origin and role of these inclusions in neurodegeneration are, however unknown. Here we show that mediators of neurodegeneration induce the vapid formation of transient or persistent rod-like inclusions containing ADF/cofilin and actin in axons and dendritesof cultured hippocampal neurons. Rods form spontaneously within neurons overexpressing active ADF/cofilin, suggesting that the activation (by dephosphorylation) of ADF/cofilin that occurs in response to neurodegenerative stimuli is sufficient to induce rod formation. Persistent rods that span the diameter of the neurite disrupt microtubules and cause degeneration of the distal neurite without killing the neuron. These findings suggest a common pathway that can lead to loss of synapses.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 19:52:35