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Titolo:
Multiple roles of the Dcdc42 GTPase during wing development in Drosophila melanogaster
Autore:
Baron, M; OLeary, V; Evans, DAP; Hicks, M; Hudson, K;
Indirizzi:
Univ Manchester, Sch Biol Sci, Manchester M13 9PT, Lancs, England Univ Manchester Manchester Lancs England M13 9PT M13 9PT, Lancs, England Astra Zeneca Pharmaceut, Macclesfield SK10 4TF, Cheshire, England Astra Zeneca Pharmaceut Macclesfield Cheshire England SK10 4TF e, England
Titolo Testata:
MOLECULAR AND GENERAL GENETICS
fascicolo: 1-2, volume: 264, anno: 2000,
pagine: 98 - 104
SICI:
0026-8925(200009)264:1-2<98:MROTDG>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-SHAPE CHANGES; PLANAR POLARIZATION; SIGNALING PATHWAY; TISSUE POLARITY; RHO-GTPASE; NOTCH; CDC42; REGULATOR; RECEPTOR; RAC1;
Keywords:
Drosophila; GTPase; Cdc42; cell polarity; Notch;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Baron, M Univ Manchester, Sch Biol Sci, Stopford Bldg,Oxford Rd, Manchester M13 9PT, Lancs, England Univ Manchester Stopford Bldg,Oxford Rd Manchester Lancs England M13 9PT
Citazione:
M. Baron et al., "Multiple roles of the Dcdc42 GTPase during wing development in Drosophila melanogaster", MOL G GENET, 264(1-2), 2000, pp. 98-104

Abstract

The Rho sub-family of GTPases. comprising Rho. Rac and Cdc42, regulates many biological processes. including morphogenesis, cell polarity, migration,the cell cycle and gene expression. It is important to develop genetic approaches to allow the dissection, in vivo, of the mechanisms of GTPase regulation and signal transmission, and their biological consequences. In this regard, wing development in Drosophila melanogaster is an excellent model system. To investigate the functions of the Drosophila Cdc42 GTPase (Dcdc42),we generated phenotypes during wing development, by expression of the dominant-negative N17 and L89 mutants of Dcdc42. We have identified roles for Dcdc42 in wing growth, and in cell fate choice during the development of thewing veins and the peripheral nervous system. Reduction of Dcdc42 signalling following over-expression of Dcdc42(N17) resulted in a broader but more diffuse domain characterised by wing-margin sensory bristles. This was correlated with a broadened stripe of Il wingless expression along the dorsal-ventral boundary of third-instar wing imaginal discs. Together with genetic interactions with loss- and gain-of-function Notch alleles, these data support a role for wild-type Dcdc42 as a negative regulator of Notch signalling.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/21 alle ore 10:07:57