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Titolo:
Notch4 and Jagged-1 induce microvessel differentiation of rat brain endothelial cells
Autore:
Uyttendaele, H; Closson, V; Wu, GY; Roux, F; Weinmaster, G; Kitajewski, J;
Indirizzi:
Columbia Univ Coll Phys & Surg, Dept Pathol & OB GYN, New York, NY 10032 USA Columbia Univ Coll Phys & Surg New York NY USA 10032 w York, NY 10032 USA Hop Fernand Widal, INSERM, U26, F-75010 Paris, France Hop Fernand Widal Paris France F-75010 NSERM, U26, F-75010 Paris, France Univ Calif Los Angeles, Sch Med, Dept Biol Chem, Los Angeles, CA 90095 USAUniv Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA
Titolo Testata:
MICROVASCULAR RESEARCH
fascicolo: 2, volume: 60, anno: 2000,
pagine: 91 - 103
SICI:
0026-2862(200009)60:2<91:NAJIMD>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEOPLASTIC TRANSFORMATION; DROSOPHILA-MELANOGASTER; TRANSMEMBRANE PROTEIN; P-GLYCOPROTEIN; DELTA-HOMOLOG; MOUSE EMBRYO; EXPRESSION; GENE; MAMMARY; LIGAND;
Keywords:
Notch4; Jagged-1; endothelial; microvessels; morphogenesis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Kitajewski, J Columbia Univ Coll Phys & Surg, Dept Pathol & OB GYN, 630 W 168th St, New York, NY 10032 USA Columbia Univ Coll Phys & Surg 630 W 168thSt New York NY USA 10032
Citazione:
H. Uyttendaele et al., "Notch4 and Jagged-1 induce microvessel differentiation of rat brain endothelial cells", MICROVASC R, 60(2), 2000, pp. 91-103

Abstract

The mouse Notch4 gene is expressed specifically in endothelial cells. Notch4/int-3, a truncated form of Notch4, acts as a constitutive activated Notch receptor. We used rat brain microvessel endothelial cells (RBE4) to studythe role of Notch4 and Jagged-1 in endothelial cell differentiation. Both Notch4/int-3 and Jagged-1 were able to induce microvessel-like structures with morphological and biochemical properties similar to brain endothelial microvessels. Ectopic expression of full-length Notch4 did not effect RBE4 cells. Activation of the Notch signal transduction pathway was measured by the induction of endogenous Notch4 and Jagged-1 genes and of Jagged-1 proteins. The observed morphological changes to RBE4 cells correlated with endogenous Notch4 and Jagged-1 gene activation. Our observations demonstrate thatNotch signaling can promote endothelial cell differentiation and morphogenesis. (C) 2000 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 20:40:13