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Titolo:
Chemokine gene expression in astrocytes of Borna disease virus-infected rats and mice in the absence of inflammation
Autore:
Sauder, C; Hallensleben, W; Pagenstecher, A; Schneckenburger, S; Biro, L; Pertlik, D; Hausmann, J; Suter, M; Staeheli, P;
Indirizzi:
Univ Freiburg, Dept Virol, Inst Med Mikrobiol & Hyg, Abt Virol, D-79104 Freiburg, Germany Univ Freiburg Freiburg Germany D-79104 Virol, D-79104 Freiburg, Germany Univ Freiburg, Abt Neuropathol, D-79106 Freiburg, Germany Univ Freiburg Freiburg Germany D-79106 pathol, D-79106 Freiburg, Germany Univ Zurich, Inst Virol, CH-8057 Zurich, Switzerland Univ Zurich Zurich Switzerland CH-8057 irol, CH-8057 Zurich, Switzerland
Titolo Testata:
JOURNAL OF VIROLOGY
fascicolo: 19, volume: 74, anno: 2000,
pagine: 9267 - 9280
SICI:
0022-538X(200010)74:19<9267:CGEIAO>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; GAMMA INDUCIBLE PROTEIN-10; BETA-CHEMOKINE; MESSENGER-RNAS; LYMPHOCYTIC CHORIOMENINGITIS; CEREBROSPINAL-FLUID; IMMUNE-RESPONSE; CELLS; INTERFERON; BRAIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
80
Recensione:
Indirizzi per estratti:
Indirizzo: Staeheli, P Univ Freiburg, Dept Virol, Inst Med Mikrobiol & Hyg, Abt Virol, Hermann Herder Str 11, D-79104 Freiburg, Germany Univ Freiburg Hermann Herder Str 11 Freiburg Germany D-79104
Citazione:
C. Sauder et al., "Chemokine gene expression in astrocytes of Borna disease virus-infected rats and mice in the absence of inflammation", J VIROLOGY, 74(19), 2000, pp. 9267-9280

Abstract

Borna disease virus (BDV) causes CD8(+) T-cell-mediated meningoencephalitis in immunocompetent mice and rats, thus providing a valuable animal model for studying the mechanisms of virus-induced central nervous system (CNS) immunopathology. Chemokine-mediated leukocyte recruitment to the CNS is a crucial step in the development of neurological disease. We found increased mRNA levels of IP-10 and other chemokines in brains of adult rats following infection with BDV. The marked increase in chemokine gene expression at about day 8 postinfection seemed to immediately precede the inflammatory process. In brains of rats infected as newborns, in which inflammation was only mild and transient, sustained expression of IP-10 and RANTES genes was observed. In situ hybridization studies revealed that astrocytes were the majorsource of IP-10 mRNAs in brains of rats infected as newborns and as adults. In brains of infected mice lacking CD8(+) cells (beta 2m(0/0)), transcripts encoding IP-10 and RANTES were also observed. IP-10 transcripts were also present in a small number of scattered astrocytes of infected knockout mice lacking mature B and T cells as well as functional alpha/beta and gamma interferon receptors, indicating that BDV can induce chemokine synthesis inthe absence of interferons and other B- or T-cell-derived cytokines. Thesedata provide strong evidence that CNS-resident cells are involved in the early localized host immune response to infection with BDV and support the concept that chemokines are pivotal for the initiation of virus-induced CNS inflammation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 08:18:54