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Titolo:
Graft vasculopathy and tolerance: Does the balance of Th cells contribute to graft vasculopathy?
Autore:
Hamano, K; Bashuda, H; Ito, H; Shirasawa, B; Okumura, K; Esato, K;
Indirizzi:
Yamaguchi Univ, Sch Med, Dept Surg 1, Yamaguchi 7558505, Japan Yamaguchi Univ Yamaguchi Japan 7558505 Surg 1, Yamaguchi 7558505, Japan Juntendo Univ, Sch Med, Dept Immunol, Bunkyo Ku, Tokyo 1138421, Japan Juntendo Univ Tokyo Japan 1138421 munol, Bunkyo Ku, Tokyo 1138421, Japan
Titolo Testata:
JOURNAL OF SURGICAL RESEARCH
fascicolo: 1, volume: 93, anno: 2000,
pagine: 28 - 34
SICI:
0022-4804(200009)93:1<28:GVATDT>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSPLANTED MOUSE HEARTS; CORONARY ARTERIOSCLEROSIS; MONOCLONAL-ANTIBODIES; PERIPHERAL TOLERANCE; ALLOGRAFT-REJECTION; CARDIAC ALLOGRAFTS; INTERFERON-GAMMA; IN-VIVO; BLOCKADE; CD4;
Keywords:
heart; transplantation; graft vasculopathy; cytokine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Hamano, K Yamaguchi Univ, Sch Med, Dept Surg 1, Yamaguchi 7558505, Japan Yamaguchi Univ Yamaguchi Japan 7558505 amaguchi 7558505, Japan
Citazione:
K. Hamano et al., "Graft vasculopathy and tolerance: Does the balance of Th cells contribute to graft vasculopathy?", J SURG RES, 93(1), 2000, pp. 28-34

Abstract

Background Cardiac allograft vasculopathy (CAV) is sometimes observed eventhough the allograft may survive indefinitely. In this study, me examined whether or not the preferential activation of Th2-type cells prevents the development of CAV. Methods. Hearts from C56BL/10 mice were transplanted heterotopically into the abdominal cavities of C3H.He recipient mice, and monoclonal antibodies (mAbs) to T-cell receptor (TCR) alpha beta or CD80/CD86 were administered after transplantation. The incidence of CAV was then examined histologically. To investigate the relative Th1/Th2 balance, the levels of IFN gamma and IL4 in the transplanted hearts were measured. Results. Indefinite heart graft survival was observed in mice treated witheither the anti-TCR alpha beta or anti-CD80/CD86 mAbs and these mice accepted donor-type (C57BL/10) skin grafts but rejected those from a third party(BALB/c). Evidence of CAV was found in the mice treated with the anti-TCR alpha beta mAb, but CAV did not develop in the mice treated with anti-CD80/CD86 mAbs. Preferential activation of Th2-type cells was dominant in the tolerant mice treated with anti-TCR alpha beta mAb, but it was not dominant in the tolerant mice treated with anti-CD80/CD86 mAbs. Conclusion. These findings suggest that the dominance of Th2-type cells does not prevent allograft vasculopathy, (C) 2000 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 20:09:46