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Titolo:
Sex- and estrous cycle-related differences in the effects of acute antipsychotic drug administration on neurotensin-containing neurons in the rat brain
Autore:
Kinkead, B; Lorch, SM; Owens, MJ; Nemeroff, CB;
Indirizzi:
Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Lab Neuropsychopharmacol, Atlanta, GA 30322 USA Emory Univ Atlanta GA USA 30322 uropsychopharmacol, Atlanta, GA 30322 USA
Titolo Testata:
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
fascicolo: 1, volume: 295, anno: 2000,
pagine: 205 - 211
SICI:
0022-3565(200010)295:1<205:SAECDI>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNOREACTIVE NEURONS; NUCLEUS-ACCUMBENS; STRIATAL DOPAMINE; LUTEINIZING-HORMONE; PREOVULATORY SURGE; GENDER DIFFERENCES; PREOPTIC AREA; NEUROMEDIN-N; FEMALE RAT; SCHIZOPHRENIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Nemeroff, CB Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Lab Neuropsychopharmacol, Suite 4000 WMRB,1639 Pierce Dr, Atlanta, GA 30322 USA Emory Univ Suite 4000 WMRB,1639 Pierce Dr Atlanta GA USA 30322
Citazione:
B. Kinkead et al., "Sex- and estrous cycle-related differences in the effects of acute antipsychotic drug administration on neurotensin-containing neurons in the rat brain", J PHARM EXP, 295(1), 2000, pp. 205-211

Abstract

The effects of a single injection of haloperidol (2.0 mg/kg), a typical antipsychotic drug, on neurotensin (NT) concentrations and NT/neuromedin N (NT/NN) mRNA expression in adult female and male rats were examined. There were significant estrous cycle stage-related differences in both NT concentrations and NT/NN mRNA expression in female control rats. Although acute administration of haloperidol increased NT concentrations and NT/NN mRNA expression in the caudate/putamen and nucleus accumbens of both male and female rats, haloperidol did not increase NT/NN mRNA expression during diestrus 2 or NT concentrations during proestrus in the nucleus accumbens of female rats. These results indicate the presence of both sex- and estrous cycle-related differences in the regulation of NT-containing neurons and in the effects of antipsychotic drug administration on the NT system of the rat brain.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 16:12:46