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Titolo:
Modifications in the phosphoinositide signaling pathway by adrenal glucocorticoids in rat brain: Focus on phosphoinositide-specific phospholipase C and inositol 1,4,5-trisphosphate
Autore:
Dwivedi, Y; Rizavi, HS; Rao, JS; Pandey, GN;
Indirizzi:
Univ Illinois, Dept Psychiat MC 912, Inst Psychiat, Coll Med, Chicago, IL 60612 USA Univ Illinois Chicago IL USA 60612 chiat, Coll Med, Chicago, IL 60612 USA
Titolo Testata:
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
fascicolo: 1, volume: 295, anno: 2000,
pagine: 244 - 254
SICI:
0022-3565(200010)295:1<244:MITPSP>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASE-C; ALPHA-SUBUNITS; RECEPTOR; EXPRESSION; DEPRESSION; BINDING; CORTICOSTEROIDS; SEROTONIN-2; METABOLISM; ISOZYMES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Dwivedi, Y Univ Illinois, Dept Psychiat MC 912, Inst Psychiat, Coll Med, 1601 W Taylor St, Chicago, IL 60612 USA Univ Illinois 1601 W Taylor St Chicago IL USA 60612 L 60612 USA
Citazione:
Y. Dwivedi et al., "Modifications in the phosphoinositide signaling pathway by adrenal glucocorticoids in rat brain: Focus on phosphoinositide-specific phospholipase C and inositol 1,4,5-trisphosphate", J PHARM EXP, 295(1), 2000, pp. 244-254

Abstract

The hypothalamic-pituitary-adrenal (HPA) axis has been shown to be involved in mood and behavior. The possibility that adrenal glucocorticoids regulate components of the phosphatidylinositol (PI) signal transduction pathway was investigated. Two different doses of corticosterone (CORT) pellets (50 or 100 mg) were implanted in normal and bilaterally adrenalectomized (ADX) rats, and CORT regulation of the expression of G(q) alpha protein, phospholipase C (PLC) isozymes, inositol 1,4,5-trisphosphate receptor (IP3R) isoforms, and of PI-PLC activity, [H-3]IP3 binding to IP(3)Rs, and IP3 levels were measured in various brain areas after 1 or 14 days. Fourteen days of CORTpellet implantation into normal rats dose dependently decreased PI-PLC activity and selectively the mRNA and protein expression of PLC beta 1 isozymein cortex and hippocampus. Bilateral ADX caused the opposite changes in these measures, and simultaneous CORT pellet implantation into ADX rats reversed these effects. Furthermore, 14 days of CORT treatment of normal rats increased [H-3]IP3 binding to IP(3)Rs and decreased IP3 levels in cortex, hippocampus, and cerebellum, without any changes in expression of IP3R-I, IP3R-II, or IP3R-III isoform. On the other hand, ADX decreased [H-3]IP3 bindingand increased levels of IP3, and simultaneous CORT treatment of ADX rats prevented these changes. ADX or CORT treatment had no significant effects onthe expression of G(q/11) alpha protein. These results suggest that manipulation of the HPA axis alters various components of the PI signaling pathway in rat brain, which may have physiological relevance to the HPA axis-mediated changes in mood and behavior.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 01:23:12