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Titolo:
HELLP syndrome
Autore:
Rath, W; Faridi, A; Dudenhausen, JW;
Indirizzi:
Univ Hosp, Dept Gynecol & Obstet, Aachen, Germany Univ Hosp Aachen Germany v Hosp, Dept Gynecol & Obstet, Aachen, Germany Humboldt Univ, Dept Obstet, Charite, Berlin, Germany Humboldt Univ Berlin Germany niv, Dept Obstet, Charite, Berlin, Germany
Titolo Testata:
JOURNAL OF PERINATAL MEDICINE
fascicolo: 4, volume: 28, anno: 2000,
pagine: 249 - 260
SICI:
0300-5577(2000)28:4<249:HS>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELEVATED LIVER-ENZYMES; LOW PLATELET COUNT; SEVERE PREECLAMPSIA-ECLAMPSIA; RANDOMIZED CONTROLLED TRIAL; EXPECTANT MANAGEMENT; MATERNAL MORBIDITY; SENSITIVE MARKER; WEEKS GESTATION; HEMOLYSIS; PREGNANCY;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Rath, W Univ Aachen, Klinium, Rhein Westfal TH Aachen, Frauenklin, Pauwelsstr 30, D-52074 Aachen, Germany Univ Aachen Pauwelsstr 30 Aachen Germany D-52074 Aachen, Germany
Citazione:
W. Rath et al., "HELLP syndrome", J PERIN MED, 28(4), 2000, pp. 249-260

Abstract

HELLP syndrome is a serious, life-threatening form of pre-eclampsia with atypical laboratory triad. The incidence of the disease is reported as being 0.17-0.85% of ail live births. There has been, to date, neither reliable early recognition nor effective prevention of HELLP syndrome. As a result of endothelial dysfunction, activation of intravascular coagulation occurs with fibrin deposition in the capillaries and consecutive microcirculation disorders. The disease manifests itself on average between 32-34 weeks' gestation. HELLP syndrome will occur postpartum in up to 30% of the cases. The clinical cardinal symptom of the disease is right upper quadrant pain or epigastric pain accompanied with nausea, vomiting and malaise. In 20% of the cases with HELLP syndrome there is no hypertension and 5-15% of the pregnant patients present a low level of proteinuria or none at all. The early recognition of hemolysis is most sensitively managed by the determination of the serum haptoglobin. The increase of the aspartate transaminase (AST) and the alanine transaminase (ALT) often precedes a decrease in platelets. The course of HELLP syndrome is incalculable. It is universally agreed that a pregnancy from 32-34 weeks should be immediately delivered. Before 32-34 weeks, expectant management is generally possible in a perinatal center. The frequency for a repeated hypertensive disease in pregnancy ranges from 27% to 48%.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 15:38:11