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Titolo:
Selective corticotropin-releasing factor type 1 receptor antagonist blocksconditioned fear-induced release of noradrenaline in the hypothalamic paraventricular nucleus of rats
Autore:
Otagiri, A; Wakabayashi, I; Shibasaki, T;
Indirizzi:
Nippon Med Sch, Dept Physiol, Bunkyo Ku, Tokyo 1138602, Japan Nippon Med Sch Tokyo Japan 1138602 siol, Bunkyo Ku, Tokyo 1138602, Japan Nippon Med Sch, Dept Med, Bunkyo Ku, Tokyo 1138602, Japan Nippon Med Sch Tokyo Japan 1138602 Med, Bunkyo Ku, Tokyo 1138602, Japan
Titolo Testata:
JOURNAL OF NEUROENDOCRINOLOGY
fascicolo: 10, volume: 12, anno: 2000,
pagine: 1022 - 1026
SICI:
0953-8194(200010)12:10<1022:SCFT1R>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RIBONUCLEIC-ACID; LOCUS-CERULEUS NEURONS; NOREPINEPHRINE RELEASE; STRIA TERMINALIS; VENTRAL MEDULLA; BED NUCLEUS; FOOD-INTAKE; STRESS; BRAIN; COERULEUS;
Keywords:
corticotropin-releasing factor receptor antagonist; conditioned fear; noradrenaline; paraventricular nucleus; microdialysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Shibasaki, T Nippon Med Sch, Dept Physiol, Bunkyo Ku, 1-1-5 Sendgai, Tokyo1138602, Japan Nippon Med Sch 1-1-5 Sendgai Tokyo Japan 1138602 8602, Japan
Citazione:
A. Otagiri et al., "Selective corticotropin-releasing factor type 1 receptor antagonist blocksconditioned fear-induced release of noradrenaline in the hypothalamic paraventricular nucleus of rats", J NEUROENDO, 12(10), 2000, pp. 1022-1026

Abstract

The effects of conditioned fear on the release of noradrenaline in the hypothalamic paraventricular nucleus (PVN) and the involvement of corticotropin-releasing factor (CRF) receptor type 1 (CRFR1) in conditioned fear-induced changes in noradrenaline release were examined by intracerebral microdialysis in rats. Conditioned fear was produced by placing animals into a box where they had previously been exposed to a 5-min period of electric footshock, 135 min prior to the start of experiment. Conditioned fear for 20 min produced a significant increase in the release of noradrenaline in the PVN. Intraperitoneal preadministration of a selective nonpeptidic CRFR1 antagonist, CRA1000, completely blocked the conditioned fear-induced release of noradrenaline. These results suggest that CRFR1 is involved in the release of noradrenaline in the hypothalamic PVN induced by conditioned fear.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 01:53:23