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Titolo:
Cloning of the murine thymic stromal lymphopoietin (TSLP) receptor: Formation of a functional heteromeric complex requires interleukin 7 receptor
Autore:
Park, LS; Martin, U; Garka, K; Gliniak, B; Di Santo, JP; Muller, W; Largaespada, DA; Copeland, NG; Jenkins, NA; Farr, AG; Ziegler, SF; Morrissey, PJ; Paxton, R; Sims, JE;
Indirizzi:
Immunex Res & Dev Corp, Dept Biochem, Seattle, WA 98101 USA Immunex Res & Dev Corp Seattle WA USA 98101 iochem, Seattle, WA 98101 USA Immunex Res & Dev Corp, Dept Biol Sci, Seattle, WA 98101 USA Immunex Res &Dev Corp Seattle WA USA 98101 ol Sci, Seattle, WA 98101 USA Immunex Res & Dev Corp, Dept Mol Biol, Seattle, WA 98101 USA Immunex Res &Dev Corp Seattle WA USA 98101 l Biol, Seattle, WA 98101 USA Inst Pasteur, Dept Immunol, F-75724 Paris, France Inst Pasteur Paris France F-75724 r, Dept Immunol, F-75724 Paris, France Inst Genet, D-50931 Cologne, Germany Inst Genet Cologne Germany D-50931Inst Genet, D-50931 Cologne, Germany NCI, Frederick Canc Res & Dev Ctr, ABL Basic Res Program, Mammalian Genet Lab, Frederick, MD 21702 USA NCI Frederick MD USA 21702 , Mammalian Genet Lab, Frederick, MD 21702 USA Univ Washington, Dept Biol Struct, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 t Biol Struct, Seattle, WA 98195 USA Virginia Mason Res Ctr, Seattle, WA 98101 USA Virginia Mason Res Ctr Seattle WA USA 98101 es Ctr, Seattle, WA 98101 USA
Titolo Testata:
JOURNAL OF EXPERIMENTAL MEDICINE
fascicolo: 5, volume: 192, anno: 2000,
pagine: 659 - 669
SICI:
0022-1007(20000904)192:5<659:COTMTS>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
GAMMA-CHAIN; CHROMOSOMAL LOCALIZATION; GENE-EXPRESSION; IL-1 RECEPTOR; B-CELLS; CYTOKINE; SUPERFAMILY; FAMILY; MICE; COMPONENT;
Keywords:
cytokine receptors; interleukin 2 receptor; interleukin 7 receptor; cytokine; DNA sequence;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Sims, JE Immunex Res & Dev Corp, Dept Biochem, 51 Univ St, Seattle, WA 98101 USA Immunex Res & Dev Corp 51 Univ St Seattle WA USA 98101 98101 USA
Citazione:
L.S. Park et al., "Cloning of the murine thymic stromal lymphopoietin (TSLP) receptor: Formation of a functional heteromeric complex requires interleukin 7 receptor", J EXP MED, 192(5), 2000, pp. 659-669

Abstract

The,cellular receptor for murine thymic stromal lymphopoietin (TSLP) was detected in a variety of murine, but not human myelomonocytic cell Lines by radioligand binding. cDNA clones encoding the receptor were isolated from amurine T helper cell cDNA library. TSLP receptor (TSLPR) is a member of the hematopoietin receptor family. Transfection of TSLPR cDNA resulted in only low affinity binding. Cotransfection of the interleukin 7 (IL-7)R alpha chain cDNA resulted in conversion to high affinity binding. TSLP did not activate cells from IL7R alpha(-/-) mice, but did activate cells h-om gamma c(-/-) mice. Thus, the functional TSLPR requires the IL-7R alpha chain, but not the gamma c chain for signaling.

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Documento generato il 25/09/20 alle ore 05:17:26