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Titolo:
Thymidine phosphorylase expression in normal and hyperplastic endometrium
Autore:
Sivridis, E; Giatromanolaki, A; Koukourakis, MI; Bicknell, R; Harris, AL; Gatter, KC;
Indirizzi:
Democritus Univ Thrace, Gen Hosp, Dept Pathol, Alexandroupolis 68100, Greece Democritus Univ Thrace Alexandroupolis Greece 68100 upolis 68100, Greece Univ Thessaloniki, Sch Med, Dept Radiotherapy & Oncol, Larisa 41222, Greece Univ Thessaloniki Larisa Greece 41222 rapy & Oncol, Larisa 41222, Greece Univ Oxford, John Radcliffe Hosp, Dept Cellular Sci, Oxford OX3 9DU, England Univ Oxford Oxford England OX3 9DU Cellular Sci, Oxford OX3 9DU, England Univ Oxford, John Radcliffe Hosp, Imperial Canc Res Fund, Med Oncol Unit, Oxford OX3 9DU, England Univ Oxford Oxford England OX3 9DU d Oncol Unit, Oxford OX3 9DU, England
Titolo Testata:
JOURNAL OF CLINICAL PATHOLOGY
fascicolo: 9, volume: 53, anno: 2000,
pagine: 704 - 708
SICI:
0021-9746(200009)53:9<704:TPEINA>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR; IMMUNOHISTOCHEMICAL LOCALIZATION; LUNG-CANCER; ANGIOGENESIS; TISSUES; ALPHA;
Keywords:
thymidine phosphorylase; normal endometrium; hyperplastic endometrium;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Sivridis, E Democritus Univ Thrace, Gen Hosp, Dept Pathol, POB 128, Alexandroupolis 68100, Greece Democritus Univ Thrace POB 128 Alexandroupolis Greece 68100 e
Citazione:
E. Sivridis et al., "Thymidine phosphorylase expression in normal and hyperplastic endometrium", J CLIN PATH, 53(9), 2000, pp. 704-708

Abstract

Aims-To investigate the expression of thymidine phosphorylase (TP), a known angiogenic factor for endothelial cells, in normally cycling endometrium and various forms of endometrial hyperplasia. Methods-TP expression was assessed with the P-GF.44C monoclonal antibody, using the alkaline phosphatase anti-alkaline phosphatase method. Ninety twonormal and hyperplastic endometria were studied. Results-In normal proliferative endometrium, TP is found exclusively in the basal layer and the inner third of the functionalis; expression is cytoplasmic in glandular epithelium and nuclear in stromal cells. It is invariably patchy. This immunohistochemical picture remains almost unaltered during the early and mid secretory phase of the normal menstrual cycle but, most impressively, TP is expressed uniformly in the epithelium of all endometrialglands towards the end of the cycle. At this stage, expression is mixed nuclear/cytoplasmic and there is very little stromal nuclear staining. In simple endometrial hyperplasia, the staining pattern for TP is identical to normal proliferative endometrium, with a distribution that is usually limitedto a few rather weakly proliferating glands and to the adjacent periglandular stroma of the deep endometrium. The distribution is more extensive in complex and atypical endometrial hyperplasias, where a mixed nuclear/cytoplasmic pattern usually prevails over the pure cytoplasmic reaction. Conclusions-TP is expressed consistently in normal and hyperplastic endometrium, suggesting a role in physiological and pathological angiogenesis. Innormal endometrium, TP has a definite pattern of distribution, which is dependent on the phase of the menstrual cycle, whereas in all forms of endometrial hyperplasia the enzyme is randomly distributed and lacks an orderly pattern.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/08/20 alle ore 23:24:49