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Titolo:
Enantiomer separations by nonaqueous capillary electrophoresis using octakis(2,3-diacetyl-6-sulfato)-gamma-cyclodextrin
Autore:
Zhu, WH; Vigh, G;
Indirizzi:
Texas A&M Univ, Dept Chem, College Stn, TX 77842 USA Texas A&M Univ College Stn TX USA 77842 t Chem, College Stn, TX 77842 USA
Titolo Testata:
JOURNAL OF CHROMATOGRAPHY A
fascicolo: 1-2, volume: 892, anno: 2000,
pagine: 499 - 507
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONTAINING BACKGROUND ELECTROLYTES; CHIRAL RESOLVING AGENTS; PEAK SHAPE DISTORTIONS; DANSYL-AMINO ACIDS; BETA-CYCLODEXTRIN; ZONE-ELECTROPHORESIS; CO-IONS; DERIVATIVES; RESOLUTION; FAMILY;
Keywords:
enantiomer separation; nonaqueous capillary electrophoresis; background electrolyte composition; cyclodextrins; basic drugs;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Vigh, G Texas A&M Univ, Dept Chem, MS 3255,POB 300012, College Stn, TX 77842 USA Texas A&M Univ MS 3255,POB 300012 College Stn TX USA 77842 842 USA
Citazione:
W.H. Zhu e G. Vigh, "Enantiomer separations by nonaqueous capillary electrophoresis using octakis(2,3-diacetyl-6-sulfato)-gamma-cyclodextrin", J CHROMAT A, 892(1-2), 2000, pp. 499-507

Abstract

The newest member of the single-isomer isomer sulfated cyclodextrin family, octakis(2,3-diacetyl-6-sulfato)-gamma-cyclodextrin (ODAS-gamma-CD) was used for the first time as a resolving agent for the nonaqueous capillary electrophoretic separation of the enantiomers of 26 weak base pharmaceuticals in an acidic methanol background electrolyte. The solubility limit of ODAS-gamma-CD at room temperature proved to be 55 mM in this background electrolyte, which afforded good, fast enantiomer separations for most of the basicdrugs tested. For all the bases studied, the effective mobilities and separation selectivities were found to follow the predictions of the charged resolving agent migration model of electrophoretic enantiomer separations. The effective mobilities of the weakly binding weak bases remained cationic throughout the entire 0 to 45 mM ODAS-gamma-CD concentration range; separation selectivities increased as the ODAS-gamma-CD concentration was increased. The effective mobilities of the moderately binding weak bases became anionic in the 2.5 to 45 mM ODAS-gamma-CD concentration range; separation selectivities first increased as the effective mobilities approached zero, then decreased again as the ODAS-gamma-CD concentration was increased further. The effective mobilities of the strongly binding weak bases became anionic in the 0 to 2.5 mM ODAS-gamma-CD concentration range; separation selectivities decreased as the ODAS-gamma-CD concentration was increased above 2.5 mM. (C) 2000 Elsevier Science B.V. All rights reserved.

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Documento generato il 24/09/20 alle ore 11:24:45