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Titolo:
Determination of 1-(2-methoxyphenyl)piperazine derivatives of isocyanates at low concentrations by temperature-programmed miniaturized liquid chromatography
Autore:
Molander, P; Haugland, K; Lundanes, E; Thorud, S; Thomassen, Y; Greibrokk, T;
Indirizzi:
Univ Oslo, Dept Chem, N-0315 Oslo, Norway Univ Oslo Oslo Norway N-0315Univ Oslo, Dept Chem, N-0315 Oslo, Norway Natl Inst Occupat Hlth, N-0033 Oslo, Norway Natl Inst Occupat Hlth Oslo Norway N-0033 upat Hlth, N-0033 Oslo, Norway
Titolo Testata:
JOURNAL OF CHROMATOGRAPHY A
fascicolo: 1-2, volume: 892, anno: 2000,
pagine: 67 - 74
Fonte:
ISI
Lingua:
ENG
Soggetto:
PACKED CAPILLARY COLUMNS; TOLUENE DIISOCYANATE; HEXAMETHYLENE DIISOCYANATE; OCCUPATIONAL ASTHMA; GRADIENT; MICROCOLUMN; INJECTION; AMINES; AIR; TDI;
Keywords:
air analysis; temperature programming; large-volume injections; methoxyphenylpiperazine; isocyanates;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Molander, P Univ Oslo, Dept Chem, POB 1033, N-0315 Oslo, Norway Univ Oslo POB 1033 Oslo Norway N-0315 33, N-0315 Oslo, Norway
Citazione:
P. Molander et al., "Determination of 1-(2-methoxyphenyl)piperazine derivatives of isocyanates at low concentrations by temperature-programmed miniaturized liquid chromatography", J CHROMAT A, 892(1-2), 2000, pp. 67-74

Abstract

A temperature-programmed packed capillary LC method with large-volume injection on-column focusing has been developed for screening and determinationof 1-(2-methoxyphenyl)piperazine derivatives of airborne toluene-2,4-diisocyanate, toluene-2, 6-diisocyanate, hexamethylenediisocyanate and methylenebisphenyl-4,4-diisocyanate, based on sampling methods described in MDHS 25/3. Injection volumes up to 100 mu l were successfully loaded onto the 250x0.32 mm I.D. capillary column packed with 3 mu m Hypersil ODS particles. Theisocyanate derivatives were loaded at 10 degrees C and eluted by a three-step temperature program starting at 10 degrees C for 10 min, followed by a temperature ramp of 2.5 degrees C min(-1) to 45 degrees C and then 9.9 degrees C min(-1) to 90 degrees C. The mobile phase consisted of acetonitrile-acetate buffer (3% triethylamine, pH 4.5) (45:55, v/v). The isocyanate derivatives were dissolved in acetonitrile-acetate buffer (3% triethylamine, pH 4.5) (30:70, v/v) to achieve sufficient focusing. The concentration limit of detection of the individual derivatives utilizing an "U" shaped flow cellwith a 8.0 mm light path and an injection volume of 100 mu l was 44, 87, 43 and 210 pg ml(-1) for toluene-2,6-diisocyanate, hexamethylenediisocyanate, toluene-2,4-diisocyanate and methylenebisphenyl-4,4-diisocyanate, respectively. Within the investigated concentration range, 10-500 ng ml(-1), the linear calibration curves gave correlation coefficients ranging from 0.994 to 0.998. The repeatability of the method with regard to retention time and peak height ranged from 0.3 to 1.1% and 1.1 to 2.3% (n=9) relative standarddeviation, respectively. The average recovery of the method, with regard to toluene-2,4-diisocyanate, was 97.7+/-1.6% (n=9). (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 22:47:51