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Titolo:
Apoptosis and the antiphospholipid syndrome
Autore:
Rauch, J; Subang, R; DAgnillo, P; Koh, JS; Levine, JS;
Indirizzi:
McGill Univ, Res Inst, Dept Med, Div Rheumatol,Montreal Gen Hosp, Montreal, PQ H3G 1A4, Canada McGill Univ Montreal PQ Canada H3G 1A4 Hosp, Montreal, PQ H3G 1A4, Canada Univ Chicago, Dept Med, Renal Sect, Chicago, IL 60637 USA Univ Chicago Chicago IL USA 60637 Med, Renal Sect, Chicago, IL 60637 USA
Titolo Testata:
JOURNAL OF AUTOIMMUNITY
fascicolo: 2, volume: 15, anno: 2000,
pagine: 231 - 235
SICI:
0896-8411(200009)15:2<231:AATAS>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYSTEMIC LUPUS-ERYTHEMATOSUS; MURINE MONOCLONAL-ANTIBODIES; MICE FOLLOWING IMMUNIZATION; CELL CLEARANCE; ANTICARDIOLIPIN ANTIBODIES; PHAGOCYTE RECOGNITION; PHOSPHOLIPID-BINDING; IMMUNE CLEARANCE; APOLIPOPROTEIN-H; GLYCOPROTEIN-I;
Keywords:
apoptosis; beta(2)-glycoprotein I; anti-phospholipid antibodies; anti-cardiolipin antibodies; systemic lupus erythematosus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Rauch, J McGill Univ, Res Inst, Dept Med, Div Rheumatol,Montreal Gen Hosp,1640 Cedar Ave, Montreal, PQ H3G 1A4, Canada McGill Univ 1640 Cedar Ave Montreal PQ Canada H3G 1A4 1A4, Canada
Citazione:
J. Rauch et al., "Apoptosis and the antiphospholipid syndrome", J AUTOIMMUN, 15(2), 2000, pp. 231-235

Abstract

The target of many antiphospholipid autoantibodies (APA) has been shown tobe a complex between anionic phospholipid (PL) and the plasma protein beta2-glycoprotein I (beta 2-GPI), but the identity of the natural target(s) and/or immunogen for APA in vivo remains undetermined. The anionic PL of cell membranes represent important potential targets and immunogens for APA. Although anionic PL are normally absent from the extracellular surface of cell membranes, they redistribute from the inner to the outer leaflet during apoptosis. We and others have shown that beta 2-GPI binds selectively to the surface of apoptotic, but not viable, cells, and that the binding of beta2-GPI to the surface of apoptotic cells generates an epitope recognized byAPA from patients with both primary antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE). In this review, we discuss recent findings, which suggest not only that apoptotic cell-bound beta 2-GPI induces the production of APA, but that apoptotic cell-bound beta 2-GPI may be the actual in vivo immunogen when heterologous beta 2-GPI is injected by non-intravenous routes. We also review briefly the potential role of oxidation in generating epitopes responsible for the recognition and induction of APA. Taken together, we believe that the available evidence supports a role for apoptotic cells as targets of APA and possible players in the induction of APA. (C) 2000 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 09:13:55