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Titolo:
Gastric retention and stability of lipidized Bowman-Birk protease inhibitor in mice
Autore:
Wang, J; Shen, WC;
Indirizzi:
Univ So Calif, Sch Pharm, Dept Pharmaceut Sci, Los Angeles, CA 90033 USA Univ So Calif Los Angeles CA USA 90033 eut Sci, Los Angeles, CA 90033 USA
Titolo Testata:
INTERNATIONAL JOURNAL OF PHARMACEUTICS
fascicolo: 1-2, volume: 204, anno: 2000,
pagine: 111 - 116
SICI:
0378-5173(20000825)204:1-2<111:GRASOL>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPIDERMAL GROWTH-FACTOR; PROTECTION; INJURY;
Keywords:
Bowman-Birk protease inhibitor; polypeptide lipidization; gastric retention; gastrointestinal absorption;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Shen, WC Univ So Calif, Sch Pharm, Dept Pharmaceut Sci, 1985 Zonal Ave,PSC404B, Los Angeles, CA 90033 USA Univ So Calif 1985 Zonal Ave,PSC 404B Los Angeles CA USA 90033 SA
Citazione:
J. Wang e W.C. Shen, "Gastric retention and stability of lipidized Bowman-Birk protease inhibitor in mice", INT J PHARM, 204(1-2), 2000, pp. 111-116

Abstract

Bowman-Birk protease inhibitor (BBI) was modified with a reversible lipidizing agent. The palmitoylated product, Pal-BBI, and BBI were iodinated and orally administered to mice using a gavage needle. A prolonged retention ofPal-BBI was found in the stomach. Furthermore, a significant amount of Pal-BBI was detected as intact polypeptide in the stomach of mice fed with Pal-BBI, while only degradation products were detected with BBI. There was also a significant increase of radioactivity in the blood and liver in mice 1.5 h post-administration of Pal-BBI. These results indicate that lipidized polypeptide can have a longer retention and lower digestion in the stomach. They also suggest that the Pal-BBI may have a higher gastrointestinal absorption than the origin;ll polypeptide. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 01:28:11