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Titolo:
Zaleplon shortens subjective sleep latency and improves subjective sleep quality in elderly patients with insomnia
Autore:
Hedner, J; Yaeche, R; Emilien, G; Farr, I; Salinas, E;
Indirizzi:
Sahlgrens Univ Hosp, Dept Clin Pharmacol, S-41345 Gothenburg, Sweden Sahlgrens Univ Hosp Gothenburg Sweden S-41345 S-41345 Gothenburg, Sweden Wyeth Ayerst Res, Paris, France Wyeth Ayerst Res Paris FranceWyeth Ayerst Res, Paris, France Amer Cyanamid Co, Madrid, Spain Amer Cyanamid Co Madrid SpainAmer Cyanamid Co, Madrid, Spain
Titolo Testata:
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
fascicolo: 8, volume: 15, anno: 2000,
pagine: 704 - 712
SICI:
0885-6230(200008)15:8<704:ZSSSLA>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
REBOUND INSOMNIA; THERAPEUTIC CONSIDERATIONS; CLINICAL PHARMACOKINETICS; BENZODIAZEPINES; HYPNOTICS; ZOLPIDEM; ANXIOLYTICS; PERFORMANCE;
Keywords:
zaleplon; elderly; insomnia; sleep; hypnotic; placebo-controlled;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Hedner, J Sahlgrens Univ Hosp, Dept Clin Pharmacol, S-41345 Gothenburg, Sweden Sahlgrens Univ Hosp Gothenburg Sweden S-41345 thenburg, Sweden
Citazione:
J. Hedner et al., "Zaleplon shortens subjective sleep latency and improves subjective sleep quality in elderly patients with insomnia", INT J GER P, 15(8), 2000, pp. 704-712

Abstract

Insomnia Is a frequent complaint In the elderly population. Hypnotic agents, including benzodiazepines, with longer pharmacological halt-lives have been associated with side effects, including residual sedation, memory impairment, and discontinuation effects. Zaleplon is a short-acting (eliminationhall-life of hour), non-benzodiazepine hypnotic that acts on the benzodiazepine type 1 site of the gamma-aminobutyric acid type A (GABA(A)) receptor complex. The pharmacology and pharmacokinetics of zaleplon suggest a safetyprofile that is improved over other hypnotics. The objective of this placebo-controlled study was to evaluate the efficacy and safety of zaleplon (5 and 10 mg) in elderly (greater than or equal to 65 years.) out patients with primary Insomnia. This was a multicenter, double blind, randomised, placebo-controlled 2-week outpatient study. Postsleep questionnaires were used to record subjective sleep variables: sleep latency, sleep duration. number of awakenings. and sleep quality. Zaleplon significantly reduced subjectivesleep Latency during both weeks of the study with both 5- and 10-mg doses. Subjective sleep quality was improved for significantly more patients treated with zaleplon 10 mg than those treated with placebo during both weeks of treatment. There was a weak indication of rebound insomnia after discontinuation of treatment with the IO-mg dose, but no significant difference In common treatment-emergent adverse events across treatment groups. Zaleplon is an effective and safe hypnotic for the treatment of insomnia in the elderly. Copyright (C) 2000 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/10/20 alle ore 10:01:59