Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Autoantibody reactivity in a case of Schnitzler's syndrome: Evidence for aTh1-like response and detection of IgG2 anti-Fc epsilon RIa antibodies
Autore:
Sperr, WR; Natter, S; Baghestanian, M; Smolen, J; Wolff, K; Binder, BR; Muller, MR; Lechner, K; Valenta, R; Valent, P;
Indirizzi:
Univ Vienna, Dept Internal Med 1, Div Hematol & Hemostaseol, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 & Hemostaseol, A-1090 Vienna, Austria Univ Vienna, Inst Gen & Expt Pathol, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 & Expt Pathol, A-1090 Vienna, Austria Univ Vienna, Dept Internal Med 3, Div Rheumatol, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 Div Rheumatol, A-1090 Vienna, Austria Univ Vienna, Dept Dermatol, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 Dept Dermatol, A-1090 Vienna, Austria Univ Vienna, Dept Vasc Biol & Thrombosis Res, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 Thrombosis Res, A-1090 Vienna, Austria Univ Vienna, Dept Surg, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 nna, Dept Surg, A-1090 Vienna, Austria
Titolo Testata:
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
fascicolo: 4, volume: 122, anno: 2000,
pagine: 279 - 286
SICI:
1018-2438(200008)122:4<279:ARIACO>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC URTICARIA; MONOCLONAL IGM; AUTOIMMUNE-DISEASE; TH1/TH2 BALANCE; UNKNOWN ORIGIN; MACROGLOBULINEMIA; CELLS; IDENTIFICATION; PROTEINS; PATIENT;
Keywords:
urticaria; monoclonal gammopathy; autoantigens; Fc epsilon RI;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Sperr, WR Univ Vienna, Dept Internal Med 1, Div Hematol & Hemostaseol, Wahringer Gurtel 18-20, A-1090 Vienna, Austria Univ Vienna Wahringer Gurtel 18-20 Vienna Austria A-1090 ustria
Citazione:
W.R. Sperr et al., "Autoantibody reactivity in a case of Schnitzler's syndrome: Evidence for aTh1-like response and detection of IgG2 anti-Fc epsilon RIa antibodies", INT A AL IM, 122(4), 2000, pp. 279-286

Abstract

Schnitzler's syndrome is a rare disease characterized by chronic urticaria, monoclonal IgM, and clinical and laboratory signs of inflammation. In a subset of patients, the urticarial lesions cause pruritus. However, the pathophysiology of the disease and the biochemical basis of urticaria are not known. We describe a female patient with Schnitzler's syndrome suffering from chronic urticaria associated with pruritus, The patient's serum was foundto contain IgG antibodies recognizing cellular components of the microvasculature. In particular, IgG3 antibodies directed against proteins (14-100 kD) expressed in cultured dermal microvascular endothelial cells and mast cells, were found by immunoblotting. Moreover, IgG2 antibodies specific for the alpha-chain of the Fc epsilon RI were detectable. However, the autoantibodies did not mediate histamine release in mast cells or basophils. In patients with IgM paraproteinemia who did not have Schnitzler's syndrome, antibodies against endothelial/mast cells or Fc epsilon RI were not detectable. In summary, we describe subclass-specific IgG reactivity against microvascular endothelial cells and mast cells indicating Th1 autoimmunity in a patient with Schnitzler's syndrome. Whether such autoantibodies are recurrently produced in patients with Schnitzler's syndrome and play a role in the pathophysiology of the disease remains to be determined. Copyright (C) 2000 S. Karger AG. Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 12:37:59