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Titolo:
Leukocyte recruitment during pulmonary Cryptococcus neoformans infection
Autore:
Huffnagle, GB; Traynor, TR; McDonald, RA; Olszewski, MA; Lindell, DM; Herring, AC; Toews, GB;
Indirizzi:
Univ Michigan, Sch Med, Div Pulm, Ann Arbor, MI USA Univ Michigan Ann Arbor MI USA gan, Sch Med, Div Pulm, Ann Arbor, MI USA
Titolo Testata:
IMMUNOPHARMACOLOGY
fascicolo: 3, volume: 48, anno: 2000,
pagine: 231 - 236
SICI:
0162-3109(20000725)48:3<231:LRDPCN>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
MONOCYTE CHEMOATTRACTANT PROTEIN-1; CD8+ T-CELLS; CCR2 CHEMOKINE RECEPTOR; TUMOR-NECROSIS-FACTOR; FUNCTIONAL EXPRESSION; MOLECULAR-CLONING; NITRIC-OXIDE; MEDIATED-IMMUNITY; GAMMA-INTERFERON; AFFERENT PHASE;
Keywords:
fungi; lungs; chemokines; lymphocyte; chemokine receptor; macrophage;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Huffnagle, GB Univ Michigan, Med Ctr, Dept Internal Med, Div Pulm & Crit Care Med, 6301 MSRB III,Box 0642, Ann Arbor, MI 48109 USA Univ Michigan 6301MSRB III,Box 0642 Ann Arbor MI USA 48109
Citazione:
G.B. Huffnagle et al., "Leukocyte recruitment during pulmonary Cryptococcus neoformans infection", IMMUNOPHARM, 48(3), 2000, pp. 231-236

Abstract

Leukocyte recruitment to the site of infection by the encapsulated yeast Cryptococcus neoformans is critical for clearance of the infection. We review data from our lab that chemokines, such as the CC chemokines MCP-1 and MIP-1 alpha, are important mediators of leukocyte recruitment during C. neoformans infection. In addition, studies in CC chemokine receptor knockout mice have demonstrated that CCR2 and CCR5 are required not only for leukocyte recruitment but also for other aspects of immune response development and innate imunity to C. neoformans. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 23:41:03