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Titolo:
Synaptic plasticity in the hippocampal area CA1-subiculum projection: Implications for theories of memory
Autore:
OMara, SM; Commins, S; Anderson, M;
Indirizzi:
Univ Dublin Trinity Coll, Dept Psychol, Dublin 2, Ireland Univ Dublin Trinity Coll Dublin Ireland 2 ept Psychol, Dublin 2, Ireland
Titolo Testata:
HIPPOCAMPUS
fascicolo: 4, volume: 10, anno: 2000,
pagine: 447 - 456
SICI:
1050-9631(2000)10:4<447:SPITHA>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM DEPRESSION; PAIRED-PULSE FACILITATION; SPATIAL FIRING PATTERNS; NEURONS IN-VITRO; PREFRONTAL CORTEX; PLACE CELLS; ENTORHINAL CORTEX; DENTATE GYRUS; EFFERENT CONNECTIONS; ALZHEIMERS-DISEASE;
Keywords:
subiculum; LTP; LTD; hippocampal-cortical interaction; synaptic plasticity; freely moving;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
67
Recensione:
Indirizzi per estratti:
Indirizzo: O'Mara, SM Univ Dublin Trinity Coll, Dept Psychol, Dublin 2, Ireland Univ Dublin Trinity Coll Dublin Ireland 2 , Dublin 2, Ireland
Citazione:
S.M. O'Mara et al., "Synaptic plasticity in the hippocampal area CA1-subiculum projection: Implications for theories of memory", HIPPOCAMPUS, 10(4), 2000, pp. 447-456

Abstract

This paper reviews investigations of synaptic plasticity in the major, andunderexplored, pathway from hippocampal area CA1 to the subiculum. This brain area is the major synaptic relay for the majority of hippocampal area CA1 neurons, making the subiculum the last relay of the hippocampal formation prior to the cortex. The subiculum thus has a very major role in mediating hippocampal-cortical interactions. We demonstrate that the projection from hippocampal area CA1 to the subiculum sustains plasticity on a number of levels. We show that this pathway is capable of undergoing both long-term potentiation (LTP) and paired-pulse facilitation (PPF, a short-term plastic effect). Although we failed to induce long-term depression (LTD) of this pathway with low-frequency stimulation (LFS) and two-pulse stimulation (TPS),both protocols can induce a "late-developing" potentiation of synaptic transmission. We further demonstrate that baseline synaptic transmission can be dissociated from paired-pulse stimulation of the same pathway; we also show that it is possible, using appropriate protocols, to change PPF to paired-pulse depression, thus revealing subtle and previously undescribed mechanisms which regulate short-term synaptic plasticity. Finally, we successfully recorded from individual subicular units in the freely-moving animal, andprovide a description of the characteristics of such neurons in a pellet-chasing task. We discuss the implications of these findings in relation to theories of the biological consolidation of memory. (C) 2000 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:05:36