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Titolo:
Hippocampo-prefrontal cortex pathway: Anatomical and electrophysiological characteristics
Autore:
Thierry, AM; Gioanni, Y; Degenetais, E; Glowinski, J;
Indirizzi:
Coll France, INSERM U114, Chaire Neuropharmacol, F-75231 Paris 05, France Coll France Paris France 05 ire Neuropharmacol, F-75231 Paris 05, France
Titolo Testata:
HIPPOCAMPUS
fascicolo: 4, volume: 10, anno: 2000,
pagine: 411 - 419
SICI:
1050-9631(2000)10:4<411:HCPAAE>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHASEOLUS-VULGARIS LEUCOAGGLUTININ; MESOCORTICAL DA SYSTEM; NUCLEUS-ACCUMBENS; BASAL GANGLIA; VENTRAL PALLIDUM; RHESUS-MONKEY; TOPOGRAPHICAL ORGANIZATION; ANTEROGRADE TRANSPORT; AFFERENT CONNECTIONS; EXCITATORY RESPONSES;
Keywords:
nucleus accumbens; CA1; subiculum; dopaminergic ascending systems;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Thierry, AM Coll France, INSERM U114, Chaire Neuropharmacol, 11 Pl Marcelin Berthelot,F-75231 Paris 05, France Coll France 11 Pl Marcelin Berthelot Paris France 05 , France
Citazione:
A.M. Thierry et al., "Hippocampo-prefrontal cortex pathway: Anatomical and electrophysiological characteristics", HIPPOCAMPUS, 10(4), 2000, pp. 411-419

Abstract

The hippocampus, the prefrontal cortex, and imterconnected neural circuitsare implicated in several aspects of cognitive and memory processes. The present review is dedicated to the description of the anatomo-functional characteristics of the hippocampo-prefrontal pathway and related neuronal circuits in the rat. This pathway, which originates from the hippocampal CA1/subiculum fields, innervates the prelimbic/medial orbital areas of the prefrontal cortex (PL/MO). Its synaptic influence on cortical pyramidal neurons consists in an early monosynaptic excitation followed by an inhibition and, in some cases, a late excitation. These later effects are likely due to thesubsequent activation of the local cortical network. PL/MO areas and the CA1/subiculum both send projections to the nucleus accumbens, a region of the ventral striatum which is particularly implicated in goal-directed behavior. Therefore, emphasis is placed on respective projections from PL/MO areas and from the CA1/subiculum on the "core" and the "shell" regions of the nucleus accumbens, as well as on their interconnected circuits. Signals which are directed to the prefrontal cortex through these circuits might modulate hippocampo-prefrontal inputs. Finally, the direct and/or indirect relationships of the hippocampus, prefrontal cortex, and nucleus accumbens with the ventral tegmental area/substantia nigra pars compacta complex (VTA/SNC) (where dopamine neurons are located) will also be described, because these neurons are known to modulate synaptic transmission and plasticity in theirtarget structures and to play a fundamental rose in motivational processes. (C) 2000 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 09:24:34