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Titolo:
Tanshinone II-A inhibits low density lipoprotein oxidation in vitro
Autore:
Niu, XL; Ichimori, K; Yang, X; Hirota, Y; Hoshiai, K; Li, M; Nakazawa, H;
Indirizzi:
Tokai Univ, Sch Med, Dept Physiol, Kanagawa 2591193, Japan Tokai Univ Kanagawa Japan 2591193 Dept Physiol, Kanagawa 2591193, Japan Guangzhou Coll Tradit Chinese Med, Guangzhou, Peoples R China Guangzhou Coll Tradit Chinese Med Guangzhou Peoples R China les R China
Titolo Testata:
FREE RADICAL RESEARCH
fascicolo: 3, volume: 33, anno: 2000,
pagine: 305 - 312
SICI:
1071-5762(2000)33:3<305:TIILDL>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL-CELLS; ANTIOXIDANT PROPERTIES; LIPID-PEROXIDATION; LDL; ATHEROSCLEROSIS; PEROXYNITRITE; BINDING; DIHYDRORHODAMINE-123; DEGRADATION; INJURY;
Keywords:
tanshinone; antioxidant; low density lipoprotein; oxidation; free radical;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Nakazawa, H Tokai Univ, Sch Med, Dept Physiol, Kanagawa 2591193, Japan Tokai Univ Kanagawa Japan 2591193 l, Kanagawa 2591193, Japan
Citazione:
X.L. Niu et al., "Tanshinone II-A inhibits low density lipoprotein oxidation in vitro", FREE RAD RE, 33(3), 2000, pp. 305-312

Abstract

Tanshinone II-A (TSII-A) is a major component of Salvia miltorrhiza Bunge which has long been used for preventing and ameliorating anginal pain in China. However the effect of TSII-A on low density lipoprotein (LDL) oxidation has not been studied. The present study was performed to investigate the effects of TSII-A on LDL oxidation using four oxidizing systems, including copper-, peroxyl radical- and peroxynitrite-initiated and macrophage-mediated LDL oxidation. LDL oxidation was measured in terms of formation of thiobarbituric acid-reactive substances (TBARS), relative electrophoretic mobility (REM) on agarose gel and lag time. In all four systems, TSII-A has apparent antioxidative effects against LDL oxidation, as evidenced by its dose-dependent inhibition of TEARS formation, prolongation of lag time and suppression of increased REM. Regarding the mechanism underlying its antioxidative effect, TSII-A neither scavenged superoxide nor peroxynitrite. It also did not chelate copper. But it has mild peroxyl radical scavenging activity. The direct binding to LDL particles and conformational change of LDL structure by TSII-A were suggested, because it increased negative charge of LDL which was shown by increased REM on agarose gel. In conclusion, TSII-A is an effective antioxidant against LDL oxidation in vitro. The underlying mechanism appears to be related to its peroxyl radical scavenging and LDL binding activity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 12:29:34