Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Potential role of oxidized lipids and lipoproteins in antioxidant defense
Autore:
Parthasarathy, S; Santanam, N; Ramachandran, S; Meilhac, O;
Indirizzi:
Emory Univ, Sch Med, Dept Obstet & Gynecol, Atlanta, GA 30322 USA Emory Univ Atlanta GA USA 30322 t Obstet & Gynecol, Atlanta, GA 30322 USA
Titolo Testata:
FREE RADICAL RESEARCH
fascicolo: 3, volume: 33, anno: 2000,
pagine: 197 -
SICI:
1071-5762(2000)33:3<197:PROOLA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; E-DEFICIENT MICE; VASCULAR ENDOTHELIAL-CELLS; LECITHIN-CHOLESTEROL ACYLTRANSFERASE; MEMBRANE PHOSPHOLIPID PEROXIDATION; HERITABLE HYPERLIPIDEMIC RABBITS; CORONARY-ARTERY ATHEROSCLEROSIS; MANGANESE SUPEROXIDE-DISMUTASE; MOUSE PERITONEAL-MACROPHAGES; RANDOMIZED CONTROLLED TRIAL;
Keywords:
LDL; oxidative stress; exercise; estradiol; antioxidant;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
216
Recensione:
Indirizzi per estratti:
Indirizzo: Parthasarathy, S Emory Univ, Sch Med, Dept Obstet & Gynecol, Atlanta, GA 30322 USA Emory Univ Atlanta GA USA 30322 l, Atlanta, GA 30322 USA
Citazione:
S. Parthasarathy et al., "Potential role of oxidized lipids and lipoproteins in antioxidant defense", FREE RAD RE, 33(3), 2000, pp. 197

Abstract

The atherogenic oxidative modification of low-density lipoprotein is suggested to occur in the aortic intima. There is reasonable evidence to suggestthat antioxidants might be beneficial in preventing or retarding the progression of atherosclerosis, Exercise, estrogens, and substitution of polyunsaturated fat for saturated fat are beneficial in the prevention of atherosclerosis. Yet, paradoxically, they are capable of inducing an oxidative stress. To reconcile with this paradox, we postulate that under certain conditions an oxidative stress might be beneficial by inducing antioxidant enzymesin arterial cells. However, those with genetic deficiency in antioxidant enzymes or those who poorly respond to oxidative stress or those with overwhelming plasma oxidative stress might need additional antioxidant protection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 22:58:50