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Titolo:
Effectiveness of antiretroviral therapy initiated before the age of 2 months in infants vertically infected with human immunodeficiency virus type 1
Autore:
Hainaut, M; Peltier, CA; Gerard, M; Marissens, D; Zissis, G; Levy, J;
Indirizzi:
CHU St Pierre, Dept Paediat, B-1000 Brussels, Belgium CHU St Pierre Brussels Belgium B-1000 Paediat, B-1000 Brussels, Belgium CHU St Pierre, Dept Internal Med, B-1000 Brussels, Belgium CHU St Pierre Brussels Belgium B-1000 rnal Med, B-1000 Brussels, Belgium VUB, CHU St Pierre, AIDS Reference Lab, Brussels, Belgium VUB Brussels Belgium U St Pierre, AIDS Reference Lab, Brussels, Belgium
Titolo Testata:
EUROPEAN JOURNAL OF PEDIATRICS
fascicolo: 10, volume: 159, anno: 2000,
pagine: 778 - 782
SICI:
0340-6199(200010)159:10<778:EOATIB>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIV-1 INFECTION; TRANSMISSION; COMBINATION; ZIDOVUDINE; REPLICATION; DIDANOSINE; REDUCTION; DNA;
Keywords:
paediatrics; antiretroviral therapy; HIV-1 infection; reverse transcriptase inhibitors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Levy, J CHU St Pierre, Dept Paediat, 322 Rue Haute, B-1000 Brussels, Belgium CHU St Pierre 322 Rue Haute Brussels Belgium B-1000 sels, Belgium
Citazione:
M. Hainaut et al., "Effectiveness of antiretroviral therapy initiated before the age of 2 months in infants vertically infected with human immunodeficiency virus type 1", EUR J PED, 159(10), 2000, pp. 778-782

Abstract

The effectiveness and tolerance of antiretroviral therapy with a combination of three reverse transcriptase inhibitors starting at the time of diagnosis (before 2 months of age) was evaluated in four infants with vertically acquired HIV-1 infection. Plasma HIV-1 RNA levels ranged from 230,000 to 1,000,000 copies;ml before onset of triple therapy and fell below 50 copies/ml at 12 to 33 weeks of life in three of the infants. These three children, currently aged 158, 105 and 72 weeks, are asymptomatic, have normal lymphocyte subsets and no hypergammaglobulinaemia. Two children experienced a profound reduction in the amount of proviral DNA detected in blood and have become HIV-1 seronegative, although one of them has had HIV-1 RNA detectable on a single occasion at 114 weeks of life (303 copies;ml). Transient interruption of therapy resulted in a rapid but reversible increase in HIV-1 RNA levels in the third child and was associated with the production of HIV-specific antibodies. The fourth child whose parents were not compliant to treatment and follow-up had a poor virological response. Conclusion Early treatment of vertically acquired human immunodeficiency virus type 1 infection with three reverse transcriptase inhibitors is well tolerated and can result in such suppression of viral replication that specific antibodies are not produced, that proviral DNA falls to the lower limitof quantitation in blood and that all clinical and immunological manifestations of infection are avoided. Parental adhesion is crucial to the effectiveness of therapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 11:25:41