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Titolo:
A single CTL clone can recognize a naturally processed HIV-1 epitope presented by two different HLA class I molecules
Autore:
Tomiyama, H; Yamada, N; Komatsu, H; Hirayama, K; Takiguchi, M;
Indirizzi:
Kumamoto Univ, Ctr AIDS Res, Div Viral Immunol, Kumamoto 8600811, Japan Kumamoto Univ Kumamoto Japan 8600811 al Immunol, Kumamoto 8600811, Japan Ajinomoto Co Inc, Cent Res Labs, Kawasaki, Kanagawa 210, Japan Ajinomoto Co Inc Kawasaki Kanagawa Japan 210 awasaki, Kanagawa 210, Japan Self Def Force Hosp, Sapporo, Hokkaido, Japan Self Def Force Hosp SapporoHokkaido Japan osp, Sapporo, Hokkaido, Japan
Titolo Testata:
EUROPEAN JOURNAL OF IMMUNOLOGY
fascicolo: 9, volume: 30, anno: 2000,
pagine: 2521 - 2530
SICI:
0014-2980(200009)30:9<2521:ASCCCR>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYTOTOXIC T-LYMPHOCYTES; IMMUNODEFICIENCY-VIRUS; HLA-B-ASTERISK-3501 MOLECULES; PEPTIDE-BINDING; CELLS; ANTIGENS; HLA-B35; HEPATITIS; RESPONSES; MOTIFS;
Keywords:
peptide; CTL epitope; TCR; HLA class I; CTL clone;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Takiguchi, M Kumamoto Univ, Ctr AIDS Res, Div Viral Immunol, 2-2-1 Honjo, Kumamoto 8600811, Japan Kumamoto Univ 2-2-1 Honjo Kumamoto Japan 8600811 0811, Japan
Citazione:
H. Tomiyama et al., "A single CTL clone can recognize a naturally processed HIV-1 epitope presented by two different HLA class I molecules", EUR J IMMUN, 30(9), 2000, pp. 2521-2530

Abstract

Although it is known that a single peptide can be recognized by CTL restricted to two MHC class I alleles, there is no direct evidence for presentation of a single peptide by two MHC class I molecules. Furthermore, it is unclear whether such peptides are presented to the same T cell or to differentT cells. Our previous study suggested that CTL recognition of the human immunodeficiency virus-1 (HIV-1) Pot HIV-B35-SF2-24 epitope (IPLTEEAEL) occurs via both HLA-B35 and HLA-B51 restriction. Here we provide the first direct evidence that a single CTL clone can recognize this peptide presented by both HLA-B35 and HLA-B51. Furthermore, we directly purified this peptide eluted from both HLA-B*3501 and HLA-B*5101 molecules isolated from target cells infected with HIV-1 recombinant vaccinia virus. These results demonstrate that HIV-B35-SF2-24 is a naturally processed peptide which is presented by both HLA-B*3501 and HLA-B*5101. TCR analysis of one CTL clone suggested that it is a single clone. B*3501-SF2-24-tetrameric complexes inhibited bothHLA-B*3501-and HLA-B*5101-restricted recognition of this clone, suggestingthat the TCR of this clone cross-recognize the structure of both HLA classI-peptide complexes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 15:23:42