Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Interleukin 7 can enhance antigen-specific cytotoxic-T-lymphocyte and/or Th2-type immune responses in vivo
Autore:
Sin, JI; Kim, J; Patchuk, C; Weiner, DB;
Indirizzi:
Univ Penn, Dept Pathol & Lab Med, Sch Med, Philadelphia, PA 19104 USA UnivPenn Philadelphia PA USA 19104 , Sch Med, Philadelphia, PA 19104 USA Wyeth Lederle Vaccines & Pediat, Malvern, PA 19355 USA Wyeth Lederle Vaccines & Pediat Malvern PA USA 19355 alvern, PA 19355 USA
Titolo Testata:
CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY
fascicolo: 5, volume: 7, anno: 2000,
pagine: 751 - 758
SICI:
1071-412X(200009)7:5<751:I7CEAC>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
HERPES-SIMPLEX-VIRUS; TYPE-1 GLYCOPROTEIN-D; STIMULATORY FACTOR NKSF; HUMAN PERIPHERAL-BLOOD; IN-VIVO; INTERFERON-GAMMA; IFN-GAMMA; PROTECTIVE IMMUNITY; CYTOKINE PROFILES; DNA IMMUNOGENS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Weiner, DB Univ Penn, Dept Pathol & Lab Med, Sch Med, 505 Stellar Chance Lab,422 Curie Dr, Philadelphia, PA 19104 USA Univ Penn 505 Stellar Chance Lab,422 Curie Dr Philadelphia PA USA 19104
Citazione:
J.I. Sin et al., "Interleukin 7 can enhance antigen-specific cytotoxic-T-lymphocyte and/or Th2-type immune responses in vivo", CL DIAG LAB, 7(5), 2000, pp. 751-758

Abstract

Interleukin 7 (IL-7) protein has been reported to be important in the development of cytotoxic-T-lymphocyte (CTL) responses. However, other studies also support a partial Th2 phenotype for this cytokine. In an effort to clarify this unusual conflict, we compared IL-7 along vith IL-12 (Th1 central) and IL-IO (Th2 control) for its ability to induce antigen (Ag)-specific CTLand Th1- versus Th2-type immune responses using a well established DNA vaccine model. In particular, IL-7 codelivery showed a significant increase inimmunoglobulin G1 (IgG1) levels compared to IgG2a levels. IL-7 coinjectionalso decreased production of Th1-type cytokine IL-2, gamma interferon, andthe chemokine RANTES but increased production of the Th2-type cytokine IL-10 and the similarly biased chemokine MCP-1. In herpes simplex virus (HSV) challenge studies, IL-7 coinjection decreased the survival rate after lethal HSV type 2 (HSV-2) challenge compared with go plasmid vaccine alone in a manner similar to IL-10 coinjection, whereas IL-12 coinjection enhanced theprotection, further supporting that IL-7 drives immune responses to the Th2 type, resulting in reduced protection against HSV-2 challenge. Moreover, coinjection with human immunodeficiency virus type 1 env and gag/pol genes plus IL-12 or IL-7 cDNA enhanced Ag-specific CTLs, while coinjection with IL-10 cDNA failed to influence CTL induction. Thus, IL-7 could drive Ag-specific Th2-type cellular responses and/or CTL responses. These results support that CTLs could be induced by IL-7 in a Th2-type cytokine and chemokine environment in vivo. This property of IL 7 allows for an alternative pathwayfor CTL development which has important implications for host-pathogen responses.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 09:47:26