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Titolo:
Coronary heart disease in smokers - Vitamin C restores coronary microcirculatory function
Autore:
Kaufmann, PA; Gnecchi-Ruscone, T; di Terlizzi, M; Schafers, KP; Luscher, TF; Camici, PG;
Indirizzi:
Hammersmith Hosp, Imperial Coll Sch Med, MRC, Ctr Clin Sci, London W12 0NN, England Hammersmith Hosp London England W12 0NN lin Sci, London W12 0NN, England Univ Hosp, Zurich, Switzerland Univ Hosp Zurich SwitzerlandUniv Hosp, Zurich, Switzerland
Titolo Testata:
CIRCULATION
fascicolo: 11, volume: 102, anno: 2000,
pagine: 1233 - 1238
SICI:
0009-7322(20000912)102:11<1233:CHDIS->2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYOCARDIAL BLOOD-FLOW; POSITRON EMISSION TOMOGRAPHY; ENDOTHELIUM-DEPENDENT DILATION; HEALTHY-YOUNG ADULTS; NONINVASIVE QUANTIFICATION; N-13 AMMONIA; CALCIUM-ANTAGONISTS; CIGARETTE-SMOKING; PASSIVE SMOKING; ARTERY DISEASE;
Keywords:
blood flow; coronary arteries; circulation; tomography; smoking; vitamins;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Camici, PG Hammersmith Hosp, Imperial Coll Sch Med, MRC, Ctr Clin Sci, London W12 0NN, England Hammersmith Hosp London England W12 0NN ndon W12 0NN, England
Citazione:
P.A. Kaufmann et al., "Coronary heart disease in smokers - Vitamin C restores coronary microcirculatory function", CIRCULATION, 102(11), 2000, pp. 1233-1238

Abstract

Background-Coronary endothelial function and vasomotion are impaired in smokers without coronary disease, and this is thought to be due to increased oxidative stress. Methods and Results-We used positron emission tomography to measure the coronary flow reserve, an integrated measure of coronary flow, through both the large epicardial coronary arteries and the microcirculation in 11 smokers and 8 control subjects before and after administration of the antioxidantvitamin C, At baseline, coronary flow reserve was reduced by 21% in smokers compared with control subjects (P < 0.05) but was normalized after vitamin C, whereas the drug had no effect in control subjects. Conclusions-The present study is the first to demonstrate that the noxiousprooxidant effects of smoking extend beyond the epicardial arteries to thecoronary microcirculation and affect the regulation of myocardial blood flow. Vitamin C restores coronary microcirculatory responsiveness and impaired coronary flow reserve in smokers, which provides evidence that the damaging effect of smoking is at least in part accounted for by an increased oxidative stress.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 16:35:45