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Titolo:
Clinical trials in coronary angiogenesis: Issues, problems, consensus - Anexpert panel summary
Autore:
Simons, M; Bonow, RO; Chronos, NA; Cohen, DJ; Giordano, FJ; Hammond, HK; Laham, RJ; Li, W; Pike, M; Sellke, FW; Stegmann, TJ; Udelson, JE; Rosengart, TK;
Indirizzi:
Harvard Univ, Sch Med, BIDMC, Angiogenesis Res Ctr, Boston, MA 02215 USA Harvard Univ Boston MA USA 02215 giogenesis Res Ctr, Boston, MA 02215 USA Harvard Univ, Sch Med, BIDMC, Div Cardiothorac Surg, Boston, MA 02215 USA Harvard Univ Boston MA USA 02215 Cardiothorac Surg, Boston, MA 02215 USA Northwestern Univ, Sch Med, Div Cardiol, Chicago, IL USA Northwestern Univ Chicago IL USA , Sch Med, Div Cardiol, Chicago, IL USA Atlanta Cardiol, Atlanta, GA USA Atlanta Cardiol Atlanta GA USAAtlanta Cardiol, Atlanta, GA USA Yale Univ, Sch Med, Div Cardiol, New Haven, CT USA Yale Univ New Haven CTUSA Univ, Sch Med, Div Cardiol, New Haven, CT USA Chiron Corp, Sunnyvale, CA USA Chiron Corp Sunnyvale CA USAChiron Corp, Sunnyvale, CA USA VA Med Ctr, San Diego, CA USA VA Med Ctr San Diego CA USAVA Med Ctr, San Diego, CA USA Univ Calif San Diego, San Diego, CA 92103 USA Univ Calif San Diego San Diego CA USA 92103 iego, San Diego, CA 92103 USA Angiogenesis Fdn, Cambridge, MA USA Angiogenesis Fdn Cambridge MA USAAngiogenesis Fdn, Cambridge, MA USA Fulda Hosp, Dept Thorac & Cardiovasc Surg, Fulda, Germany Fulda Hosp Fulda Germany Dept Thorac & Cardiovasc Surg, Fulda, Germany New England Med Ctr, Div Cardiol, Boston, MA 02111 USA New England Med Ctr Boston MA USA 02111 Div Cardiol, Boston, MA 02111 USA Tufts Univ, Sch Med, Boston, MA 02111 USA Tufts Univ Boston MA USA 02111Tufts Univ, Sch Med, Boston, MA 02111 USA Northwestern Univ, Evanston Hosp, Div Cardiothorac Surg, Chicago, IL 60611USA Northwestern Univ Chicago IL USA 60611 othorac Surg, Chicago, IL 60611USA
Titolo Testata:
CIRCULATION
fascicolo: 11, volume: 102, anno: 2000,
pagine: E73 - E86
SICI:
0009-7322(20000912)102:11<E73:CTICAI>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
FIBROBLAST-GROWTH-FACTOR; COLLATERAL-DEPENDENT MYOCARDIUM; QUALITY-OF-LIFE; ENDOTHELIAL PROGENITOR CELLS; POSITRON-EMISSION-TOMOGRAPHY; TUMOR-INDUCED ANGIOGENESIS; ISCHEMIC-HEART-DISEASE; ARTERY DISEASE; GENE-TRANSFER; IN-VIVO;
Keywords:
angiogenesis; coronary disease; growth substances; revascularization; clinical trials;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
95
Recensione:
Indirizzi per estratti:
Indirizzo: Simons, M Harvard Univ, Sch Med, BIDMC, Angiogenesis Res Ctr, SL-423,330 Brookline Ave, Boston, MA 02215 USA Harvard Univ SL-423,330 Brookline Ave Boston MA USA 02215 15 USA
Citazione:
M. Simons et al., "Clinical trials in coronary angiogenesis: Issues, problems, consensus - Anexpert panel summary", CIRCULATION, 102(11), 2000, pp. E73-E86

Abstract

The rapid development of angiogenic growth factor therapy for patients with advanced ischemic heart disease over the last 5 years offers hope of a new treatment strategy based on generation of new blood supply in the diseased heart. However, as the field of therapeutic coronary angiogenesis is maturing from basic and preclinical investigations to clinical trials, many newand presently unresolved issues are coming into focus. These include in-depth understanding of the biology of angiogenesis, selection of appropriate patient populations for clinical trials, choice of therapeutic end points and means of their assessment, choice of therapeutic strategy (gene versus protein delivery), route of administration, and the side effect profile. Thepresent article presents a summary statement of a panel of experts actively working in the field, convened by the Angiogenesis Foundation and the Angiogenesis Research Center during the 72nd meeting of the American Heart Association to define and achieve a consensus on the challenges facing development of therapeutic angiogenesis for coronary disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 13:04:55